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There are new flu vaccines on offer for 2024. Should I get one? What do I need to know?

<p><em><a href="https://theconversation.com/profiles/allen-cheng-94997">Allen Cheng</a>, <a href="https://theconversation.com/institutions/monash-university-1065">Monash University</a></em></p> <p>Influenza is a common respiratory infection. Although most cases are relatively mild, flu can cause more severe illness in young children and older people.</p> <p>Influenza virtually <a href="https://pubmed.ncbi.nlm.nih.gov/33243355/">disappeared</a> from Australia during the first years of the COVID-19 pandemic when public health restrictions reduced contact between people. Since 2022, it has returned to a seasonal pattern, although the flu season has started and peaked a few months earlier than before 2020.</p> <p>It’s difficult to predict the intensity of the flu season at this point in the year, but we can sometimes get clues from the northern hemisphere. There, the season <a href="https://www.who.int/tools/flunet">started</a> <a href="https://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html">earlier</a> than usual for the third year running (peaking in early January rather than late February/March), with a similar number of reported cases and hospitalisations to the previous year.</p> <p>Influenza vaccines are recommended annually, but there are now an increasing number of different vaccine types. Here’s what to know about this year’s shots, available from <a href="https://www.health.gov.au/topics/immunisation/vaccines/influenza-flu-vaccine">this month</a>.</p> <h2>What goes into a flu vaccine?</h2> <p>Like other vaccines, influenza vaccines work by “training” the immune system on a harmless component of the influenza virus (known as an antigen), so it can respond appropriately when the body encounters the real virus.</p> <p>Influenza strains are constantly changing due to genetic mutation, with the pace of genetic change <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421855">much higher</a> than for SARS-CoV-2 (the virus that causes COVID). The strains that go into the vaccine are <a href="https://www.who.int/teams/global-influenza-programme/vaccines/who-recommendations">reviewed</a> twice each year by the World Health Organization (WHO), which selects vaccine strains to match the next season’s predicted circulating strains.</p> <p>All current influenza vaccines in <a href="https://www.tga.gov.au/resources/publication/meeting-statements/aivc-recommendations-composition-influenza-vaccines-australia-2024">Australia</a> contain four different strains (known as quadrivalent vaccines). One of the strains appeared to <a href="https://www.nejm.org/doi/full/10.1056/NEJMp2314801">disappear</a> during the COVID pandemic, and the WHO has recently <a href="https://cdn.who.int/media/docs/default-source/influenza/who-influenza-recommendations/vcm-southern-hemisphere-recommendation-2024/202309_qanda_recommendation.pdf?sfvrsn=7a6906d1_5">recommended</a> dropping this strain from the vaccine. It’s expected trivalent (three strain) vaccines will become available in the near future.</p> <h2>What’s different about new flu vaccines?</h2> <p>There are eight brands of flu vaccines <a href="https://www.health.gov.au/resources/publications/atagi-statement-on-the-administration-of-seasonal-influenza-vaccines-in-2024?language=en">available</a> in Australia in 2024. These include egg-based vaccines (Vaxigrip Tetra, Fluarix Tetra, Afluria Quad, FluQuadri and Influvac Tetra), cell-based vaccines (Flucelvax Quad), adjuvanted vaccines (Fluad Quad) and high-dose vaccines (Fluzone High-Dose Quad).</p> <p>Until recently, the process of manufacturing flu vaccines has remained similar. Since the development of the influenza vaccine in the <a href="https://www.who.int/news-room/spotlight/history-of-vaccination/history-of-influenza-vaccination">1940s</a>, influenza viruses were grown in chicken eggs, then extracted, inactivated, purified and processed to make up the egg-based vaccines that are still used widely.</p> <p>However, there have been several enhancements to influenza vaccines in recent years.</p> <p>Older people’s immune systems tend not to respond as strongly to vaccines. In some flu vaccines, adjuvants (components that stimulate the immune system) are included with the influenza antigens. For example, an adjuvant is used in the Fluad Quad vaccine, recommended for over 65s. Studies <a href="https://ncirs.org.au/sites/default/files/2021-02/Adjuvanted%20influenza%20vaccine%20vs%20standard%20dose%20influenza%20vaccine%20SoF%20EP%20E2D%20tables_26%20Feb%202021_Final.pdf">suggest</a> adjuvanted influenza vaccines are slightly better than standard egg-based vaccines without adjuvant in older people.</p> <p>An alternative approach to improving the immune response is to use higher doses of the vaccine strains. An example is Fluzone High-Dose Quad – another option for older adults – which contains the equivalent of four doses of a standard influenza vaccine. Studies <a href="https://ncirs.org.au/sites/default/files/2022-05/HD%20vs%20sIV%20SoF%20EP%20E2D_March%202022_Final.pdf">suggest</a> the high dose vaccine is better than the standard dose vaccine (without an adjuvant) in preventing hospitalisation and complications in older people.</p> <p>Other manufacturers have updated the manufacturing process. Cell-based vaccines, such as Flucelvax Quad, use cells instead of eggs in the manufacturing process. Other vaccines that are <a href="https://www.cdc.gov/flu/prevent/advances.htm">not yet available</a> also use different technologies. In the past, <a href="https://pubmed.ncbi.nlm.nih.gov/31151913/">manufacturing issues</a> with egg-based vaccines have reduced their effectiveness. Using an alternative method of production provides some degree of insurance against this in the future.</p> <h2>What should I do this year?</h2> <p>Given indications this year’s flu season may be earlier than usual, it’s probably safest to get your vaccine early. This is particularly <a href="https://www.health.gov.au/resources/publications/atagi-statement-on-the-administration-of-seasonal-influenza-vaccines-in-2024?language=en">important</a> for those at highest risk of severe illness, including older adults (65 years and over), those with chronic medical conditions, young children (six months to five years) and Aboriginal and Torres Strait Islander people. Influenza vaccines are also recommended in pregnancy to protect both the mother and the baby for the first months of life.</p> <p>Influenza vaccines are widely available, including at GP clinics and pharmacies, while many workplaces have occupational programs. For high-risk groups, <a href="https://www.health.gov.au/topics/immunisation/vaccines/influenza-flu-vaccine">four of the vaccines</a> are subsidised by the Australian government through the <a href="https://www.health.gov.au/our-work/national-immunisation-program">National Immunisation Program</a>.</p> <p>In older people, a number of vaccines are now recommended: <a href="https://www.health.gov.au/sites/default/files/2024-03/atagi-statement-on-the-administration-of-covid-19-vaccines-in-2024.pdf">COVID</a> and influenza, as well as one-off courses of <a href="https://www.health.gov.au/sites/default/files/documents/2020/06/national-immunisation-program-pneumococcal-vaccination-schedule-from-1-july-2020-clinical-advice-for-vaccination-providers.pdf">pneumococcal</a> and <a href="https://www.health.gov.au/topics/immunisation/vaccines/shingles-herpes-zoster-immunisation-service">shingles</a> vaccines. In general, most vaccines can be given in the same visit, but talk to your doctor about which ones you need.</p> <h2>Are there side effects?</h2> <p>All influenza vaccines can <a href="https://www.health.gov.au/topics/immunisation/vaccines/influenza-flu-vaccine">cause</a> a sore arm and sometimes more generalised symptoms such as fever and tiredness. These are expected and reflect the immune system reacting appropriately to the vaccine, and are mostly mild and short-term. These side effects are slightly more common in <a href="https://ncirs.org.au/sites/default/files/2021-02/Adjuvanted%20influenza%20vaccine%20vs%20standard%20dose%20influenza%20vaccine%20SoF%20EP%20E2D%20tables_26%20Feb%202021_Final.pdf">adjuvanted</a> and <a href="https://ncirs.org.au/sites/default/files/2022-05/HD%20vs%20sIV%20SoF%20EP%20E2D_March%202022_Final.pdf">high dose</a> vaccines.</p> <p>As with all medications and vaccines, allergic reactions such as anaphylaxis can occur after the flu vaccine. All vaccine providers are trained to recognise and respond to anaphylaxis. People with egg allergies should discuss this with their doctor, but in general, <a href="https://www.allergy.org.au/patients/food-allergy/egg-allergy-flu-vaccine">studies suggest</a> they can safely receive any (including egg-based) influenza vaccines.</p> <p>Serious side effects from the influenza vaccine, such as Guillain-Barré syndrome, a neurological complication, are very rare (one case per million people vaccinated). They are <a href="https://pubmed.ncbi.nlm.nih.gov/23810252/">thought</a> to be less common after influenza vaccination than after infection with influenza.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/226623/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/allen-cheng-94997">Allen Cheng</a>, Professor of Infectious Diseases, <a href="https://theconversation.com/institutions/monash-university-1065">Monash University</a></em></p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/there-are-new-flu-vaccines-on-offer-for-2024-should-i-get-one-what-do-i-need-to-know-226623">original article</a>.</em></p>

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What is minoxidil, the anti-balding hair growth treatment? Here’s what the science says

<p><a href="https://theconversation.com/profiles/jacinta-l-johnson-1441348">Jacinta L. Johnson</a>, <em><a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a></em> and <a href="https://theconversation.com/profiles/kirsten-staff-1494356">Kirsten Staff</a>, <em><a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a></em></p> <p>Hair loss (also known as alopecia) often affects the scalp but can occur anywhere on the body. It’s very common and usually nothing to worry about; about <a href="https://www.sciencedirect.com/science/article/pii/S0022202X15525840">half of Australian men</a> show signs of visible baldness at age 50 and <a href="https://www.sciencedirect.com/science/article/pii/S0022202X15525840">over a quarter of Australian women</a> report hair thinning by the same age. It’s often genetic.</p> <p>But if you’ve noticed hair loss and are worried by it, see a GP or dermatologist for a diagnosis before trying any treatments. Products claiming to reverse hair loss are everywhere, but few have been scientifically tested for how well they work.</p> <p>One group of products that have actually been scientifically tested, however, are known as topical minoxidil products. These include products such as Regaine®.</p> <p>So, do they work? Here’s what the research evidence says, what you can realistically expect and what you need to know if you’re considering this treatment.</p> <h2>What is minoxidil – and does it work?</h2> <p>Topical minoxidil usually comes as a kind of foam or serum you apply to your scalp.</p> <p>It’s been approved by the <a href="https://www.tga.gov.au/">Therapeutic Goods Administration</a>, Australia’s regulatory authority for therapeutic goods, for the treatment of hereditary hair loss in males and females. Minoxidil is also available in tablet form, but this isn’t currently approved for hair loss (more on that later).</p> <p>So, is topical minoxidil effective? In short – yes, but the results vary widely from person to person, and it needs to be used consistently over several months to see results.</p> <p>Scientists don’t know exactly how minoxidil works. It may affect the different phases of the hair life cycle, thereby encouraging growth. It also <a href="https://www.tandfonline.com/doi/full/10.1080/09546634.2021.1945527?casa_token=KhIM_u0u8nwAAAAA:5njp_XE5cHhip454ycvU1p9p_t0VVzpjRu0ozDZ9YqNb04fmhmngWzYeiowZcG5UugLQkTVIzCcj7A">opens up blood vessels</a> near hair follicles.</p> <p>This increases blood flow, which in turn delivers more oxygen and nutrients to the hair.</p> <p>While minoxidil is unlikely to restore a full head of thick, lush, hair, it can slow down hair loss and can <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD007628.pub4/full?highlightAbstract=minoxidil">stimulate regrowth</a>.</p> <p>It is the over-the-counter option with the most evidence. Two strengths are available: 5% and 2%.</p> <p>An analysis of randomised controlled trials found minoxidil applied to the scalp twice a day increased the number of hairs per square centimetre by <a href="https://pubmed.ncbi.nlm.nih.gov/28396101/">eight to 15 hairs</a>, with the higher strength treatment having a slightly greater effect.</p> <h2>Can I use it for non-genetic balding?</h2> <p>There are many causes of hair loss. The main cause in both males and females is a hereditary condition called androgenic alopecia.</p> <p>Although topical minoxidil is only approved for use in Australia for androgenic alopecia, there is some evidence it can also help in other conditions that cause hair loss.</p> <p>For example, it may hasten hair regrowth in patients who have lost hair due to <a href="https://www.jaad.org/article/S0190-9622(96)90500-9/abstract">chemotherapy</a>.</p> <p>Unfortunately, minoxidil is not effective when the hair follicle is gone, like after a burn injury.</p> <p>Although small studies have found promising results using minoxidil to promote hair growth on the face (for <a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.13312">beard</a> or <a href="https://pubmed.ncbi.nlm.nih.gov/24471459/">eyebrow</a> enhancement), topical minoxidil products are not currently approved for this use. More research is required.</p> <h2>What else do I need to know?</h2> <p>Minoxidil won’t work well for everyone. Early in treatment you might notice a temporary increase in <a href="https://pubmed.ncbi.nlm.nih.gov/22409453/">hair shedding</a>, as it alters the hair cycle to make way for new growth. Minoxidil needs to be trialled for three to six months to determine if it’s effective.</p> <p>And as it doesn’t cure hair loss, you must <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jdv.14624?casa_token=P-zW7kDNRs8AAAAA%3AaUgUzxU7lbwBpg1BYPajOfXFhpb_mU5g_ounZ6GtjsLLkHO_AdVQ2Kf-8zZkW80ykBj3N_sOsyn392uc">continue</a> to use it each day to maintain the effect. If you stop, you will start losing the new hair growth <a href="https://www.nps.org.au/assets/medicines/1f8127a5-2a98-4013-a7c3-a53300feb0e5-reduced.pdf">within three to four months</a>.</p> <p>Minoxidil products may not be suitable for everyone. If you have any medical conditions or take any medications, you should speak with your doctor or pharmacist before using minoxidil products.</p> <p>It has not been tested for safety in <a href="https://www.nps.org.au/assets/medicines/1f8127a5-2a98-4013-a7c3-a53300feb0e5-reduced.pdf">people under 18, over 65, or those who are pregnant</a>.</p> <p>You can read the <a href="https://www.nps.org.au/medicine-finder/regaine-for-men-regular-strength-application">consumer medicines information sheet</a> for more information about using over-the-counter minoxidil products.</p> <p>Many people do not like to use minoxidil solution or foams long-term because they need to be applied everyday day, which can be inconvenient. Or they may notice side effects, such as scalp irritation and changes to hair texture.</p> <p>Some people <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jdv.14624?casa_token=P-zW7kDNRs8AAAAA%3AaUgUzxU7lbwBpg1BYPajOfXFhpb_mU5g_ounZ6GtjsLLkHO_AdVQ2Kf-8zZkW80ykBj3N_sOsyn392uc">tolerate the foam products better</a> than the solution, as the solution contains more of a compound called propylene glycol (which can irritate the skin).</p> <h2>What about the oral tablet form of minoxidil?</h2> <p>Minoxidil is also available on prescription as an oral tablet. While traditionally used for high blood pressure, it has also been used as a treatment for hair loss.</p> <p>In 2020, a <a href="https://www.jaad.org/article/S0190-9622(20)32109-5/abstract">systematic review</a> identified 17 studies involving 634 patients using oral minoxidil for various hair loss conditions.</p> <p>The authors found oral minoxidil was effective and generally well tolerated in healthy people who were having trouble using the topical products.</p> <p>The review noted oral minoxidil may increase hair growth over the whole body and may cause heart-related side effects in some patients. More research is required.</p> <p>In Australia, oral minoxidil is available under the trade name <a href="https://www.nps.org.au/assets/medicines/df29e16f-6464-4652-ba1f-a53300fed275.pdf">Loniten</a>®. However, it is currently only approved for use in high blood pressure.</p> <p>When people seek a prescription treatment for a non-approved purpose, this is called “off-label” prescribing. Off-label prescribing of oral minoxidil, potentially for use in alopecia, may have contributed to <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170338/">shortages</a> of Loniten® tablets in recent years. This can reduce availability of this medicine for people who need it for high blood pressure.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/223736/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><a href="https://theconversation.com/profiles/jacinta-l-johnson-1441348">Jacinta L. Johnson</a>, Senior Lecturer in Pharmacy Practice, <em><a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a></em> and <a href="https://theconversation.com/profiles/kirsten-staff-1494356">Kirsten Staff</a>, Senior Lecturer in Pharmacy, <em><a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a></em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/what-is-minoxidil-the-anti-balding-hair-growth-treatment-heres-what-the-science-says-223736">original article</a>.</em></p> <p><em>Image: Getty</em></p>

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Dad awarded compensation after developing heart issue from mandatory vaccine

<p>An Adelaide father is set to receive hefty compensation after a mandatory Covid jab left him with a debilitating health condition. </p> <p>In 2021 at the height of the Covid pandemic in Australia, 44-year-old Daniel Shepherd was required to receive tow Covid vaccinations, due to his hands on role at an aged care facility. </p> <p>After having two Pfizer vaccines, he suffered some adverse effects, but dismissed his symptoms as nothing serious. </p> <p>In the months after, Shepherd was required to have a booster shot when he began a new job with the Department of Child Protection in October of the same year. </p> <p>In January 2022, the father was told if we wanted to keep his job as a health and childcare worker, he needed to have the jab. </p> <p>After eventually agreeing to the booster, Shepherd has his third dose of Pfizer in late February 2022, but began suffering from chest pains just hours later. </p> <p>"It felt like someone had their knee right on my chest," he told <a href="https://www.9news.com.au/national/adelaide-news-covid-vaccine-man-to-get-government-compensation-after-developing-heart-condition/55cc0fbf-4631-4cf0-b395-8c8b6c71a43f" target="_blank" rel="noreferrer noopener"><em>9News</em>.</a></p> <p>The pain kept getting worse until he was rushed to hospital a few weeks later when he thought he was having a heart attack.</p> <p>There he was diagnosed with post-vaccine pericarditis: an inflammation of the membrane around the heart.</p> <p>His illness meant he was unable to work full time, and also meant he was unable to keep up with his young son.</p> <p>"Even today with just mild exertion [I get] chest pains and then it's followed by fatigue, like severe fatigue," Shepard said.</p> <p>"It's heartbreaking to have to say 'sorry buddy, daddy's tired'." </p> <p>Mr Shepherd decided to take legal action after he was unable to work, launching a workers compensation claim against the government.</p> <p>In a landmark ruling in mid-January, the South Australian Employment Tribunal agreed to pay weekly compensation and medical bills to Shepherd.</p> <p>Doctors were unanimous in his case that the vaccine was the cause of his inability to work, but the government argued emergency directions that were in place at the time trumped the laws around workplace injury.</p> <p>Pericarditis is meant to clear within a few months, but Shepherd's symptoms have plagued him for almost two years.</p> <p><em>Image credits: 9News</em></p>

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Millions of high-risk Australians aren’t getting vaccinated. A policy reset could save lives

<p><em><a href="https://theconversation.com/profiles/peter-breadon-1348098">Peter Breadon</a>, <a href="https://theconversation.com/institutions/grattan-institute-1168">Grattan Institute</a> and <a href="https://theconversation.com/profiles/ingrid-burfurd-1295906">Ingrid Burfurd</a>, <a href="https://theconversation.com/institutions/grattan-institute-1168">Grattan Institute</a></em></p> <p>Each year, vaccines prevent thousands of deaths and hospitalisations in Australia.</p> <p>But millions of high-risk older Australians <a href="https://grattan.edu.au/report/a-fair-shot-ensuring-all-australians-can-get-the-vaccines-they-need/">aren’t getting</a> recommended vaccinations against COVID, the flu, pneumococcal disease and shingles.</p> <p>Some people are more likely to miss out, such as migrant communities and those in rural areas and poorer suburbs.</p> <p>As our new <a href="https://grattan.edu.au/report/a-fair-shot-ensuring-all-australians-can-get-the-vaccines-they-need/">Grattan report shows</a>, a policy reset to encourage more Australians to get vaccinated could save lives and help ease the pressure on our struggling hospitals.</p> <h2>Adult vaccines reduce the risk of serious illness</h2> <p>Vaccines slash the risk of <a href="https://www.ncirs.org.au/sites/default/files/2021-03/Influenza-fact-sheet_31%20March%202021_Final.pdf">hospitalisation</a> and serious illness, <a href="https://ncirs.org.au/recent-covid-19-vaccination-highly-effective-against-death-caused-sars-cov-2-infection-older">often by more than half</a>.</p> <p>COVID has already caused more than <a href="https://www.abs.gov.au/statistics/health/causes-death/provisional-mortality-statistics/latest-release">3,000 deaths in Australia this year</a>. On average, the flu kills about <a href="https://www.doherty.edu.au/news-events/news/statement-on-the-doherty-institute-modelling">600 people a year</a>, although a bad flu season, like 2017, can mean <a href="https://www.abs.gov.au/ausstats/abs@.nsf/Lookup/by%20Subject/3303.0%7E2017%7EMain%20Features%7EAustralia's%20leading%20causes%20of%20death,%202017%7E2">several thousand deaths</a>. And pneumococcal disease may also kill <a href="https://www.aihw.gov.au/getmedia/49809836-8ead-4da5-81c4-352fa64df75b/aihw-phe-263.pdf?inline=true">hundreds</a> of people a year. Shingles is rarely fatal, but can be extremely painful and cause <a href="https://www.healthdirect.gov.au/shingles#complications">long-term nerve damage</a>.</p> <p>Even before COVID, vaccine-preventable diseases caused tens of thousands of potentially preventable hospitalisations each year – more than <a href="https://www.aihw.gov.au/reports/primary-health-care/disparities-in-potentially-preventable-hospitalisa/data">80,000 in 2018</a>.</p> <p>Vaccines offered in Australia have been tested for safety and efficacy and have been found to be <a href="https://www.health.gov.au/topics/immunisation/about-immunisation/vaccine-safety#:%7E:text=serious%20side%20effects.-,Vaccine%20safety%20monitoring,approved%20for%20use%20in%20Australia.">very safe</a> for people who are <a href="https://www.health.gov.au/topics/immunisation/when-to-get-vaccinated/national-immunisation-program-schedule">recommended to get them</a>.</p> <h2>Too many high-risk people are missing out</h2> <p>Our <a href="https://grattan.edu.au/report/roundabouts-overpasses-carparks-hauling-the-federal-government-back-to-its-proper-role-in-transport-projects">report</a> shows that before winter this year, only 60% of high-risk Australians were vaccinated against the flu.</p> <p>Only 38% had a COVID vaccination in the last six months. Compared to a year earlier, two million more high-risk people went into winter without a recent COVID vaccination.</p> <p>Vaccination rates have fallen further since. Just over one-quarter (<a href="https://www.health.gov.au/sites/default/files/2023-11/covid-19-vaccine-rollout-update-10-november-2023.pdf">27%</a>) of people over 75 have been vaccinated in the last six months. That leaves more than 1.3 million without a recent COVID vaccination.</p> <p>Uptake is also low for other vaccines. Among Australians in their 70s, <a href="https://ncirs.org.au/sites/default/files/2022-12/Coverage%20report%202021%20SUMMARY%20FINAL.pdf">less than half</a> are vaccinated against shingles and only one in five are vaccinated against pneumococcal disease.</p> <p>These vaccination rates aren’t just low – they’re also unfair. The likelihood that someone is vaccinated changes depending on where they live, where they were born, what language they speak at home, and how much they earn.</p> <p>For example, at the start of winter this year, the COVID vaccination rate for high-risk Aboriginal and Torres Strait Islander adults was only 25%. This makes them about one-third less likely to have been vaccinated against COVID in the previous six months, compared to the average high-risk Australian.</p> <p>For more than 750,000 high-risk adults who do not speak English at home, the COVID vaccination rate is below 20% – about half the level of the average high-risk adult.</p> <p>Within this group, 250,000 adults aren’t proficient in English. They were 58% less likely to be vaccinated for COVID in the previous six months, compared to the average high-risk person.</p> <p>High-risk adults who speak English at home have a flu vaccination rate of 62%. But for people from 29 other language groups, who aren’t proficient in English, the rate is less than 31%. These 39,000 people have half the vaccination rate of people who speak English at home.</p> <p>These vaccination gaps contribute to the differences in people’s health. Australians born overseas don’t just have much lower rates of COVID vaccination, they also have much higher rates of death from COVID.</p> <p>Where people live also affects vaccination rates. High-risk people living in remote and very remote areas are less likely to be vaccinated, and even within capital cities there are big differences between different areas.</p> <h2>We need to set ambitious targets</h2> <p>Australia needs a vaccination reset. A new National Vaccination Agreement between the federal and state governments should include ambitious but achievable targets for adult vaccines.</p> <p>This can build on the success of targets for childhood and adolescent vaccination, setting targets for overall uptake and for communities that are falling behind.</p> <p>The federal government should ask the Australian Technical Advisory Group on Immunisation (ATAGI) to advise on vaccination targets for COVID, flu, pneumococcal and shingles for all high-risk older adults.</p> <h2>Different solutions for different barriers</h2> <p>Barriers to vaccination range from the trivial to the profound. A new national vaccination strategy needs to dismantle high and low barriers alike.</p> <p>First, to increase overall uptake, vaccination should be easier, and easier to understand.</p> <p>The federal government should introduce vaccination “surges”, especially in the lead-up to winter, as <a href="https://www.who.int/europe/news/item/09-10-2023-vulnerable--vaccinate.-protecting-the-unprotected-from-covid-19-and-influenza">countries in Europe</a> do.</p> <p>During surges, high-risk people should be able to get vaccinated even if they have had a recent infection or injection. This will make the rules simpler and make vaccination in aged care easier.</p> <p>Surges should be reinforced with advertising explaining who should get vaccinated and why. High-risk people should get SMS reminders.</p> <p>Second, targeted policies are needed for the many people who are happy to use mainstream primary care services, but who don’t get vaccinated – for example, due to <a href="https://theconversation.com/how-can-governments-communicate-with-multicultural-australians-about-covid-vaccines-its-not-as-simple-as-having-a-poster-in-their-language-156097">language barriers</a>, or living in <a href="https://theconversation.com/over-half-of-eligible-aged-care-residents-are-yet-to-receive-their-covid-booster-and-winter-is-coming-205403">aged care</a>.</p> <p><a href="https://www.health.gov.au/our-work/phn/what-PHNs-are">Primary Health Networks</a> should get funding to coordinate initiatives such as vaccination events in aged care and disability care homes, workforce training to support culturally appropriate care, and provision of interpreters.</p> <p>Third, tailored programs are needed to reach <a href="https://www.aihw.gov.au/reports/australias-health/health-promotion">people who are not comfortable or able to access mainstream health care</a>, who have the most complex barriers to vaccination – for example, distrust of the health system or poverty.</p> <p>These communities are all very different, so one-size-fits-all programs don’t work. The pandemic showed that vaccination programs can succeed when they are designed and delivered with the communities they are trying to reach. Examples are “<a href="https://pubmed.ncbi.nlm.nih.gov/36366401/">community champions</a>” who challenge misinformation, or health services organising vaccination events where communities work, gather or <a href="https://www.theguardian.com/australia-news/2021/aug/11/hundreds-queue-for-hours-and-some-camp-overnight-at-pop-up-vaccine-clinic-in-sydneys-lakemba">worship</a>.</p> <p>These programs should get ongoing funding, but also be accountable for achieving results.</p> <p>Adult vaccines are the missing piece in Australia’s whole-of-life vaccination strategy. For the health and safety of the most vulnerable members of our community, we need to close the vaccination gap. <!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/217915/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><a href="https://theconversation.com/profiles/peter-breadon-1348098"><em>Peter Breadon</em></a><em>, Program Director, Health and Aged Care, <a href="https://theconversation.com/institutions/grattan-institute-1168">Grattan Institute</a> and <a href="https://theconversation.com/profiles/ingrid-burfurd-1295906">Ingrid Burfurd</a>, Senior Associate, Health Program, Grattan Institute, <a href="https://theconversation.com/institutions/grattan-institute-1168">Grattan Institute</a></em></p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/millions-of-high-risk-australians-arent-getting-vaccinated-a-policy-reset-could-save-lives-217915">original article</a>.</em></p>

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What are the new COVID booster vaccines? Can I get one? Do they work? Are they safe?

<p><em><a href="https://theconversation.com/profiles/paul-griffin-1129798">Paul Griffin</a>, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a></em></p> <p>As the COVID virus continues to <a href="https://pubmed.ncbi.nlm.nih.gov/36680207/">evolve</a>, so does our vaccine response. From <a href="https://www.health.gov.au/ministers/the-hon-mark-butler-mp/media/new-covid-19-vaccines-available-to-target-current-variants?language=en">December 11</a>, Australians will have access to <a href="https://www.health.gov.au/news/atagi-recommendations-on-use-of-the-moderna-and-pfizer-monovalent-omicron-xbb15-covid-19-vaccines?language=en">new vaccines</a> that offer better protection.</p> <p>These “monovalent” booster vaccines are expected to be a <a href="https://theconversation.com/cdc-greenlights-two-updated-covid-19-vaccines-but-how-will-they-fare-against-the-latest-variants-5-questions-answered-213341">better match</a> for currently circulating strains of SARS-CoV-2, the virus that causes COVID.</p> <p>Pfizer’s monovalent vaccine will be <a href="https://www.health.gov.au/ministers/the-hon-mark-butler-mp/media/new-covid-19-vaccines-available-to-target-current-variants?language=en">available</a> to eligible people aged five years and older. The Moderna monovalent vaccine can be used for those aged 12 years and older.</p> <p>Who is eligible for these new boosters? How do they differ from earlier ones? Do they work? Are they safe?</p> <h2>Who’s eligible for the new boosters?</h2> <p>The federal government has accepted the Australian Technical Advisory Group (ATAGI) recommendation to use the new vaccines, after Australia’s regulator <a href="https://www.tga.gov.au/products/covid-19/covid-19-vaccines/covid-19-vaccines-regulatory-status">approved their use last month</a>. However, vaccine eligibility has remained the same since September.</p> <p>ATAGI <a href="https://www.health.gov.au/news/atagi-recommendations-on-use-of-the-moderna-and-pfizer-monovalent-omicron-xbb15-covid-19-vaccines?language=en">recommends</a> Australians aged over 75 get vaccinated if it has been six months or more since their last dose.</p> <p>People aged 65 to 74 are recommended to have a 2023 booster if they haven’t already had one.</p> <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=315&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=315&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=315&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=396&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=396&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=396&amp;fit=crop&amp;dpr=3 2262w" alt="" /></a><figcaption><span class="caption">For people without risk factors.</span> <span class="attribution"><a class="source" href="https://www.health.gov.au/sites/default/files/2023-10/atagi-recommended-covid-19-vaccine-doses.pdf">Health.gov.au</a></span></figcaption></figure> <p>Adults aged 18 to 64 <em>with</em> underlying risk factors that increase their risk of severe COVID are also recommended to have a 2023 booster if they haven’t had one yet. And if they’ve already had a 2023 booster, they can consider an additional dose.</p> <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=311&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=311&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=311&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=391&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=391&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=391&amp;fit=crop&amp;dpr=3 2262w" alt="" /></a><figcaption><span class="caption">Advice for people with risk factors.</span> <span class="attribution"><a class="source" href="https://www.health.gov.au/sites/default/files/2023-10/atagi-recommended-covid-19-vaccine-doses.pdf">Health.gov.au</a></span></figcaption></figure> <p>For adults aged 18 to 64 <em>without</em> underlying risk factors who have already received a 2023 booster, an additional dose isn’t recommended. But if you’re aged 18 to 64 and haven’t had a booster in 2023, you can consider an additional dose.</p> <p>Additional doses aren’t recommended for children <em>without</em> underlying conditions that increase their risk of severe COVID. A primary course is not recommended for children aged six months to five years <em>without</em> additional risk factors.</p> <h2>Monovalent, bivalent? What’s the difference?</h2> <p><strong>From monovalent</strong></p> <p>The initial COVID vaccines were “monovalent”. They had one target – the original viral strain.</p> <p>But as the virus mutated, we assigned new letters of the Greek alphabet to each variant. This brings us to Omicron. With this significant change, we saw “immune evasion”. The virus had changed so much the original vaccines didn’t provide sufficient immunity.</p> <p><strong>To bivalent</strong></p> <p>So vaccines were updated to target an early Omicron subvariant, BA.1, plus the original ancestral strain. With two targets, these were the first of the “bivalent” vaccines, which were approved in Australia <a href="https://theconversation.com/omicron-specific-vaccines-may-give-slightly-better-covid-protection-but-getting-boosted-promptly-is-the-best-bet-190736">in 2022</a>.</p> <p>Omicron continued to evolve, leading to more “immune escape”, contributing to repeated waves of transmission.</p> <p>The vaccines were updated again in <a href="https://theconversation.com/havent-had-covid-or-a-vaccine-dose-in-the-past-six-months-consider-getting-a-booster-199096">early 2023</a>. These newer bivalent vaccines target two strains – the ancestral strain plus the subvariants BA.4 and BA.5.</p> <p><strong>Back to monovalent</strong></p> <p>Further changes in the virus have meant our boosters needed to be updated again. This takes us to the recent announcement.</p> <p>This time the booster targets another subvariant of Omicron known as XBB.1.5 (sometimes known as <a href="https://theconversation.com/the-kraken-subvariant-xbb-1-5-sounds-scary-but-behind-the-headlines-are-clues-to-where-covids-heading-198158">Kraken</a>).</p> <p>This vaccine is monovalent once more, meaning it has only one target. The target against the original viral strain has been removed.</p> <p>According to advice given to the World Health Organization <a href="https://www.who.int/news/item/18-05-2023-statement-on-the-antigen-composition-of-covid-19-vaccines">in May</a>, this is largely because immunity to this original strain is no longer required (it’s no longer infecting humans). Raising immunity to the original strain may also hamper the immune response to the newer component, but we’re not sure if this is occurring or how important this is.</p> <p>The United States <a href="https://theconversation.com/cdc-greenlights-two-updated-covid-19-vaccines-but-how-will-they-fare-against-the-latest-variants-5-questions-answered-213341">approved</a> XBB.1.5-specific vaccines from Pfizer and Moderna in <a href="https://www.fda.gov/news-events/press-announcements/fda-takes-action-updated-mrna-covid-19-vaccines-better-protect-against-currently-circulating">mid-September</a>. These updated vaccines have also been <a href="https://www.tga.gov.au/sites/default/files/2023-10/auspar-spikevax-xbb.1.5-231012.pdf">approved in</a> places including Europe, Canada, Japan and Singapore.</p> <p>In Australia, the Therapeutic Goods Administration (TGA) approved them <a href="https://www.tga.gov.au/products/covid-19/covid-19-vaccines/covid-19-vaccines-regulatory-status">in October</a>.</p> <h2>Do these newer vaccines work?</h2> <p>Evidence for the efficacy of these new monovalent vaccines comes from the results of research <a href="https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&amp;id=CP-2023-PI-02409-1&amp;d=20231117172310101">Pfizer</a> and <a href="https://www.tga.gov.au/resources/auspar/auspar-spikevax-xbb15">Moderna</a> submitted to the TGA.</p> <p>Evidence also comes from a <a href="https://www.medrxiv.org/content/10.1101/2023.08.22.23293434v2">preprint</a> (preliminary research available online that has yet to be independently reviewed) and an update Pfizer <a href="https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2023-09-12/10-COVID-Modjarrad-508.pdf">presented</a> to the US Centers for Disease Control.</p> <p>Taken together, the available evidence shows the updated vaccines produce good levels of antibodies in <a href="https://www.tga.gov.au/resources/auspar/auspar-spikevax-xbb15">laboratory studies</a>, <a href="https://www.medrxiv.org/content/10.1101/2023.08.22.23293434v2">in humans</a> and <a href="https://www.tga.gov.au/resources/auspar/auspar-spikevax-xbb15">mice</a> when compared to previous vaccines and when looking at multiple emerging variants, including EG.5 (sometimes known as <a href="https://theconversation.com/the-who-has-declared-eris-a-variant-of-interest-how-is-it-different-from-other-omicron-variants-211276">Eris</a>). This variant is the one causing high numbers of cases around the world currently, including in Australia. It is very similar to the XBB version contained in the updated booster.</p> <p>The updated vaccines should also cover <a href="https://theconversation.com/how-evasive-and-transmissible-is-the-newest-omicron-offshoot-ba-2-86-that-causes-covid-19-4-questions-answered-212453">BA.2.86 or Pirola</a>, according to <a href="https://www.tga.gov.au/sites/default/files/2023-10/auspar-spikevax-xbb.1.5-231012.pdf">early results</a> from clinical trials and the US <a href="https://www.cdc.gov/respiratory-viruses/whats-new/covid-19-variant.html">Centers for Disease Control</a>. This variant is responsible for a rapidly increasing proportion of cases, with case numbers growing <a href="https://twitter.com/BigBadDenis/status/1725310295596560662?s=19">in Australia</a>.</p> <p>It’s clear the virus is going to continue to evolve. So performance of these vaccines against new variants will continue to be closely monitored.</p> <h2>Are they safe?</h2> <p>The <a href="https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&amp;id=CP-2023-PI-02409-1&amp;d=20231117172310101">safety</a> of the updated vaccines has also been shown to be similar to previous versions. Studies <a href="https://www.medrxiv.org/content/10.1101/2023.08.22.23293434v2">comparing them</a> found no significant difference in terms of the adverse events reported.</p> <p>Given the availability of the updated vaccines, some countries have removed their approval for earlier versions. This is because newer versions are a closer match to currently circulating strains, rather than any safety issue with the older vaccines.</p> <h2>What happens next?</h2> <p>The availability of updated vaccines is a welcome development, however this is not the end of the story. We need to make sure eligible people get vaccinated.</p> <p>We also need to acknowledge that vaccination should form part of a comprehensive strategy to limit the impact of COVID from now on. That includes measures such as mask wearing, social distancing, focusing on ventilation and air quality, and to a lesser degree hand hygiene. Rapidly accessing antivirals if eligible is also still important, as is keeping away from others if you are infected.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/217804/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><a href="https://theconversation.com/profiles/paul-griffin-1129798"><em>Paul Griffin</em></a><em>, Professor, Infectious Diseases and Microbiology, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/what-are-the-new-covid-booster-vaccines-can-i-get-one-do-they-work-are-they-safe-217804">original article</a>.</em></p>

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9 signs you have inflammation in your body. Could an anti-inflammatory diet help?

<p><em><a href="https://theconversation.com/profiles/lauren-ball-14718">Lauren Ball</a>, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a> and <a href="https://theconversation.com/profiles/emily-burch-438717">Emily Burch</a>, <a href="https://theconversation.com/institutions/southern-cross-university-1160">Southern Cross University</a></em></p> <p>There is a lot of health buzz around the term “inflammation” right now. From new scientific <a href="https://medicalxpress.com/news/2023-07-inflammation-discovery-aging-age-related-diseases.html">discoveries</a> to <a href="https://people.com/health/gwyneth-paltrow-addresses-backlash-anti-inflammatory-diet/">celebrities</a> and social media influencers, it seems like everyone is talking about this important bodily process and its potential impact on our health.</p> <p>“<a href="https://www.nature.com/articles/s41574-018-0059-4">Inflammaging</a>” is a specific term you may also have seen. It’s an age-related increase in persistent, low-grade inflammation in blood and tissue, which is a strong risk factor for many conditions and diseases.</p> <p>So, can an anti-inflammatory diet help reduce inflammation? Let’s take a look.</p> <h2>What is inflammation?</h2> <p>When our body becomes injured or encounters an infection, it activates defence mechanisms to protect itself. It does this by instructing our cells to fight off the invader. This fighting process <a href="https://www.nature.com/articles/s41591-019-0675-0#citeas">causes inflammation</a>, which often presents as swelling, redness and pain.</p> <p>In the short-term, inflammation is a sign your body is healing, whether from a grazed knee or a cold.</p> <p>If inflammation persists for a longer time it’s called “chronic”. That can indicate a <a href="https://www.nature.com/articles/s41467-018-05800-6">health problem</a> such as <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638313/">arthritis</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719998/#B2-ijms-20-03879">heart disease</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523054/">diabetes</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390758/">dementia</a> or other autoimmune disorders.</p> <p>The <a href="https://www.ncbi.nlm.nih.gov/books/NBK493173/">signs and symptoms</a> of chronic inflammation may be present from several months to years and include:</p> <ol> <li>persistent pain</li> <li>chronic fatigue or insomnia</li> <li>joint stiffness</li> <li>skin problems</li> <li>elevated blood markers (such as <a href="https://www.healthdirect.gov.au/c-reactive-protein-CRP-blood-test">C-reactive protein</a>)</li> <li>gastrointestinal issues (constipation, diarrhoea, acid reflux)</li> <li>depression, anxiety and mood disorders</li> <li>unintended weight gain or loss</li> <li>frequent colds or flu.</li> </ol> <h2>What role does diet play?</h2> <p>The relationship between food and inflammation is <a href="https://www.sciencedirect.com/science/article/pii/S0735109706013350">well recognised</a>. Overall, some food components may activate the immune system by producing pro-inflammatory cytokines (small proteins important in cell signaling) or reducing the production of anti-inflammatory cytokines.</p> <p>A “<a href="https://theconversation.com/clear-evidence-for-a-link-between-pro-inflammatory-diets-and-27-chronic-diseases-heres-how-you-can-eat-better-158451">pro-inflammatory diet</a>” may increase inflammation in the body over the long term. Such diets are usually low in fresh produce like fruits, vegetables and wholegrains, and high in commercially baked goods, fried foods, added sugars and red and processed meats.</p> <p>In contrast, an “<a href="https://academic.oup.com/ajcn/article/80/4/1029/4690355">anti-inflammatory</a>” diet is associated with less inflammation in the body. There is no single anti-inflammatory diet. Two well-recognised, evidence-backed examples are the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet.</p> <p>Anti-inflammatory diets typically include the following elements:</p> <p><strong>1. high in antioxidants.</strong> These compounds help the body fight free radicals or unstable atoms, that in high quantities are linked to illnesses such as cancer and heart disease. The best way to consume antioxidants is by eating lots of fruits and vegetables. Research shows frozen, dried and canned fruits and vegetables can be <a href="https://theconversation.com/frozen-and-tinned-foods-can-be-just-as-nutritious-as-fresh-produce-heres-how-201740">just as good as fresh</a></p> <p><strong>2. high in “healthy”, unsaturated fatty acids.</strong> Monounsaturated fats and omega-3-fatty acids are found in fish (sardines, mackerel, salmon and tuna), seeds, nuts, and plant-based oils (olive oil and flaxseed oil)</p> <p><strong>3. high in fibre and prebiotics.</strong> Carrots, cauliflower, broccoli and leafy greens are good sources of fibre. Prebiotics promote the growth of beneficial microorganisms in our intestines and can come from onions, leeks, asparagus, garlic, bananas, lentils and legumes</p> <p><strong>4. low in processed foods.</strong> These contain refined carbohydrates (pastries, pies, sugar-sweetened beverages, deep-fried foods and processed meats).</p> <h2>Rheumatoid arthritis, dementia, depression</h2> <p>There is mixed evidence for the role of anti-inflammatory diets in rheumatoid arthritis pain management. A recent <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706441/">2021 systematic review</a> (where researchers carefully group and examine the available evidence on a topic) found eating an anti-inflammatory diet likely leads to significantly lower pain in people with rheumatoid arthritis when compared with other diets.</p> <p>However, the 12 studies included in the review had a high risk of bias – likely because people knew they were eating healthy foods – so the confidence in the evidence was low.</p> <p>Inflammation is strongly implicated in the development of neurodegenerative diseases like <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486891/">Alzheimer’s disease and related dementia</a> and evidence suggests anti-inflammatory diets might help to protect the brain.</p> <p>A <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015034/">2016 review</a> showed an anti-inflammatory diet may be protective against cognitive impairment and dementia, but that further large randomised controlled trials are needed. A <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673721/">2021 study</a> followed 1,059 people for three years and observed their diet. They reported those with a greater pro-inflammatory diet had an increased risk of developing dementia.</p> <p>Inflammation has also been linked with mental health, with people eating a pro-inflammatory diet reporting more symptoms of <a href="https://pubmed.ncbi.nlm.nih.gov/31152670/">depression</a>. Diet is the fundamental element of <a href="https://www1.racgp.org.au/ajgp/2019/october/lifestyle-interventions-for-mental-health">lifestyle approaches</a> to managing anxiety and mental health.</p> <p>More broadly, a <a href="https://www.mdpi.com/2227-9059/9/8/922">2021 review paper</a> examined recent research related to anti-inflammatory diets and their effect on reducing inflammation associated with ageing. It found compounds commonly found in anti-inflammatory diets could help alleviate the inflammatory process derived from diseases and unhealthy diets.</p> <h2>What about turmeric?</h2> <p>A favourite on social media and vitamin shelves, turmeric is promoted as having anti-inflammatory benefits. These are linked to a specific compound called <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388087/#:%7E:text=Curcuminoids%20are%20phenolic%20compounds%20commonly,several%20important%20functions%20of%20curcuminoids.">curcumin</a>, which gives turmeric its distinctive yellow colour.</p> <p>Research suggests curcumin might act as an anti-inflammatory agent in the body but high-quality clinical trials in humans are <a href="https://www.mdpi.com/1420-3049/16/6/4567">lacking</a>. Most of the <a href="https://www.mdpi.com/1420-3049/16/6/4567">existing studies</a> have been conducted in <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.27360">lab settings</a> using cells or in <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608712/">animals</a>. So it’s unclear how much curcumin is needed to see anti-inflammatory benefits or how well <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/">we absorb it</a>.</p> <p>Overall, adding turmeric to your food may provide your body with some health benefits, but don’t rely on it to prevent or treat disease on its own.</p> <h2>Safe eating</h2> <p>Inflammation is a major factor in the link between diet and many health conditions.</p> <p>Eating an anti-inflammatory diet is considered safe, likely to support health and to prevent future chronic conditions. If you are looking for tailored dietary advice or an anti-inflammatory meal plan, it’s best to speak with an <a href="https://member.dietitiansaustralia.org.au/Portal/Portal/Search-Directories/Find-a-Dietitian.aspx">accredited practising dietitian</a>.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/210468/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/lauren-ball-14718">Lauren Ball</a>, Professor of Community Health and Wellbeing, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a> and <a href="https://theconversation.com/profiles/emily-burch-438717">Emily Burch</a>, Dietitian, Researcher &amp; Lecturer, <a href="https://theconversation.com/institutions/southern-cross-university-1160">Southern Cross University</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/9-signs-you-have-inflammation-in-your-body-could-an-anti-inflammatory-diet-help-210468">original article</a>.</em></p>

Body

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Anti-vegan chef launches clothing line against activist

<p dir="ltr">Chef John Mountain has taken his feud with vegan activist Tash Peterson to the next level by unveiling a clothing line that names and shames her and her animal rights beliefs. </p> <p dir="ltr">The Perth chef, who has taken legal action against Ms Peterson after the pair tussled during protests at his restaurant Fyre, showed off the provocative range of tank-tops, t-shirts and hoodies on his new merchandise website.</p> <p dir="ltr">The merch page, which was launched on Saturday, promises customers will love the clothing “hopefully more than Tash loves chef”.</p> <p dir="ltr">It is now selling clothing that carries the restaurant's branding and slogans such as “Pleased to meat stew”, “no animals were harmed in the making of this shirt” and “all they have done is added fuel to the Fyre”.</p> <p dir="ltr">One t-shirt design features a half-star Google-style review graphic with the words: “Absolutely f***ing chaotic Tash Peterson”, which makes fun of Ms Peterson's description of a protest and the flood of Fyre reviews posted by vegans.</p> <p dir="ltr">Another design asks. “What's the difference between a vegan and a heroin addict? The vegan keeps it to themselves.”</p> <p dir="ltr">The clothing line comes after John Mountain announced all vegans would be banned from his restaurant due to “mental health reasons”.</p> <p dir="ltr">Mountain and Peterson have clashed several times at the Perth eatery, with Peterson’s latest demonstration resulting in legal action being taken against the staunch vegan and animal rights activist. </p> <p dir="ltr">After Peterson <a href="https://oversixty.com.au/finance/legal/furious-chef-lets-loose-after-clash-with-vegan-protestors" target="_blank" rel="noopener">stormed</a> his booked-out restaurant with other activists in tow, they stood outside with a megaphone, while shouting and playing sounds of squealing pigs, moments before the altercation was caught on camera.</p> <p dir="ltr">Mountain and Peterson came to physical blows as he wrestled them out of the restaurant, as he defended his choice to retaliate against the protestors, saying he chose to stand up to the bullies to "protect my business". </p> <p dir="ltr">"Bullies come in all different shapes and sizes and these lot just happen to be the vegans."</p> <p dir="ltr"><em>Image credits: A Current Affair / Fyre</em></p>

Legal

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“Done with the vaccine”: Karl Stefanovic blasts fifth booster

<p>Karl Stefanovic has once again sparked controversy after declaring he is “done with the vaccine.”</p> <p>Karl shocked viewers after expressing concerns that the jab could cause “heart issues” as the Australian Technical Advisory Group (ATAGI) updated its vaccine recommendations. </p> <p>According to the ATAGI, as of February 20, anyone aged 18 and over who has not had the COVID vaccine or has not contracted the virus in the past six months will be eligible to get another shot - opening up a fourth dose for Aussies aged 19-29 and a fifth dose for those 65 and over. </p> <p>“As you know, I am not a glowing ambassador for more than two shots,” Stefanovic said.</p> <p>The Today show host then questioned whether another dose would be able to fight new strains of the virus, stating he is aware of people “over the age of 60 who are still incredibly nervous about getting it."</p> <p>“The other thing that I am concerned about, if I have another dose, is that I may get complications,” he said. </p> <p>The host’s guest, medical expert Dr Nick Coatsway insisted Australians aged 60 and over “needn’t be” scared of the jab but added that the conceded boosters are only a temporary solution.</p> <p>“Let’s understand the science, if you get a fifth dose your protection is enhanced for around about 8-12 weeks and then it returns after the fourth dose or the third dose,” Dr Coatsworth said.</p> <p>The ATAGI has again emphasised the importance of Aussies who are already eligible, including people over 65, to get their booster in 2023 as they remain at high risk of severe disease and death from COVID. </p> <p>Currently, there is no additional booster available to those 18 and below, with the exception of children aged 5-17 who are at high risk of developing a severe illness.</p> <p><em>Image credit: Getty</em></p>

TV

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Who’s taking COVID antivirals like Paxlovid? Hint: it helps if you’re rich

<p><em><a href="https://theconversation.com/profiles/nicole-allard-1349026">Nicole Allard</a>, <a href="https://theconversation.com/institutions/the-peter-doherty-institute-for-infection-and-immunity-2255">The Peter Doherty Institute for Infection and Immunity</a></em></p> <p>When it comes to COVID, people living in disadvantaged communities are hit with a triple whammy. First, they’re <a href="https://www.aihw.gov.au/reports-data/health-conditions-disability-deaths/covid-19/overview">more likely</a> to get infected, and when sick, are more likely to have serious disease. Second, they’re <a href="https://theconversation.com/first-covid-hit-disadvantaged-communities-harder-now-long-covid-delivers-them-a-further-blow-183908">more likely</a> to develop long COVID. Third, our <a href="https://www.mja.com.au/journal/2023/218/10/access-oral-covid-19-antivirals-community-are-eligibility-criteria-and-systems">recent research</a> suggests they’re less likely to get antivirals and when they do, it’s on average later.</p> <p>We’ve just <a href="https://www.mja.com.au/journal/2023/218/10/access-oral-covid-19-antivirals-community-are-eligibility-criteria-and-systems">published the data</a> to map how disadvantage is linked with access to COVID antiviral drugs you can take at home.</p> <p>Here’s why our findings matter and what we can do to level the playing field for this critical part of Australia’s COVID response.</p> <h2>What we did and what we found</h2> <p>Our team looked at Victorian and national prescribing data trends for the oral antiviral medications eligible Australians can take at home – Paxlovid (nirmatrelvir/ritonavir) and Lagevrio (molnupiravir).</p> <p>My health department colleagues linked data from the Pharmaceutical Benefits Scheme with information from the Victorian health department’s COVID surveillance database. They then matched levels of socioeconomic disadvantage by postcode, according to criteria from the Australian Bureau of Statistics.</p> <p>Their analysis showed people living in the most disadvantaged postcodes were 15% less likely to receive oral antivirals compared with those in the most advantaged postcodes.</p> <p>Those in the most disadvantaged postcodes were supplied with the antivirals on average a day later (three days versus two days) than those in the most advantaged postcodes.</p> <p>There are some limitations to our analysis. Not everyone who tests for COVID reports their positive result. And we suspect there may be more under-reporting of infections in disadvantaged areas.</p> <p>Nevertheless, our findings about the influence of disadvantage on antiviral supply are not surprising. In the United States, there have been <a href="https://www.cdc.gov/mmwr/volumes/71/wr/mm7125e1.htm?utm">similar results</a>.</p> <h2>Why has this happened?</h2> <p>We know <a href="https://www.health.gov.au/health-alerts/covid-19/treatments/eligibility">early access to antivirals</a>, within the first five days of symptoms starting, is important to reduce the chances of severe disease and hospitalisation in those at risk.</p> <p>So why are people in disadvantaged areas less likely to have access to COVID antivirals? The answers are multiple and complex.</p> <p>Some relate to <a href="https://link.springer.com/article/10.1007/s11069-019-03584-6/tables/1">disadvantage</a> that existed before the pandemic – for instance, poverty, homelessness, lower levels of English or formal education, and being less likely to have a regular GP.</p> <p>Some factors relate specifically to antivirals. For instance, to access antivirals, you first have to know they exist and whether you might be eligible, then know how to access them and when. There may be out-of-pocket costs to see a GP to be assessed, then there’s the cost of filling the prescription, even with a concession card.</p> <h2>How can we address this?</h2> <p>We have an opportunity to address this inequity, whether that’s by addressing social determinants of health more broadly, or specifically related to antivirals access.</p> <p>Equity depends on continuing to address the structural inequalities in our health system that create barriers to people accessing primary health services, and tailoring responses to communities.</p> <p>For instance, earlier in the pandemic we saw funding to house homeless people, provide COVID-related health care to non-English speaking communities, and for people isolated at home. These initiatives need to continue.</p> <p>Other countries have also recognised the need for more equitable access to COVID antivirals. Initiatives have included:</p> <ul> <li> <p>COVID medicine <a href="https://phlgroup.co.uk/our-services/cmdu/">delivery units</a> in the United Kingdom. These identify, triage and arrange for high-risk people to receive antivirals at home</p> </li> <li> <p><a href="https://covid19.govt.nz/testing-and-isolation/if-you-have-covid-19/medicines-to-treat-covid-19">pharmacists prescribing antivirals</a> in New Zealand, and</p> </li> <li> <p>“<a href="https://aspr.hhs.gov/TestToTreat/Pages/default.aspx#:%7E:text=To%20find%20a%20participating%20Test%20to%20Treat%20site%20near%20you%3A&amp;text=Call%20the%20Centers%20for%20Disease,more%20than%20150%20other%20languages.">test to treat</a>” services in the US. This is where people can get tested, assessed and access antivirals in one spot, in one visit.</p> </li> </ul> <h2>What needs to happen next?</h2> <p>As <a href="https://theconversation.com/were-in-another-covid-wave-but-its-not-like-the-others-206493">COVID waves continue</a>, we must focus on reducing deaths and hospitalisations. Antiviral treatments are part of our armour and equity must drive our response.</p> <p>Our ongoing COVID response should be designed with consumer input, supported by an adequately funded public health system and be data driven. Here’s what needs to happen next:</p> <ul> <li> <p>encourage a tired public to see COVID testing as an important first step to accessing antiviral treatment, and why they should consider treatment</p> </li> <li> <p>address the health care inequality in primary care (for instance, boosting timely access to a GP people can afford to visit) by increasing resourcing in areas where we know there are gaps</p> </li> <li> <p>provide culturally safe health care, delivered in community languages, co-designed with community input</p> </li> <li> <p>evaluate current and future antiviral medications</p> </li> <li> <p>communicate up-to-date information to the public and health professionals about antivirals, particularity GPs</p> </li> <li> <p>access more data on the coverage and equity of antiviral COVID treatments, to help direct us to the gaps in the health system that need to be plugged.</p> </li> </ul> <h2>Why this matters now</h2> <p>For many of us in the past year, COVID has become another “cold” we encounter and may not even bother testing. Yet, we continue to see <a href="https://www.health.gov.au/health-alerts/covid-19/weekly-reporting">deaths and hospitalisations</a> across the country.</p> <p>Serious COVID infections continue to affect our most vulnerable people. These include elderly people, especially those over 80, First Nations people, people living with a disability and people who are socioeconomically disadvantaged.</p> <p>We have a chance to ensure antivirals are used to reduce existing disparities in hospitalisation and death – not to make them worse.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/207822/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/nicole-allard-1349026">Nicole Allard</a>, Post doctoral researcher and medical epidemiologist, <a href="https://theconversation.com/institutions/the-peter-doherty-institute-for-infection-and-immunity-2255">The Peter Doherty Institute for Infection and Immunity</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/whos-taking-covid-antivirals-like-paxlovid-hint-it-helps-if-youre-rich-207822">original article</a>.</em></p>

Caring

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I’m over 65 and worried about the flu. Which vaccine should I have?

<p><em><a href="https://theconversation.com/profiles/magdalena-plebanski-1063786">Magdalena Plebanski</a>, <a href="https://theconversation.com/institutions/rmit-university-1063">RMIT University</a>; <a href="https://theconversation.com/profiles/jennifer-boer-1210047">Jennifer Boer</a>, <a href="https://theconversation.com/institutions/rmit-university-1063">RMIT University</a>; <a href="https://theconversation.com/profiles/katie-louise-flanagan-1066858">Katie Louise Flanagan</a>, <a href="https://theconversation.com/institutions/university-of-tasmania-888">University of Tasmania</a>, and <a href="https://theconversation.com/profiles/kirsty-wilson-1103649">Kirsty Wilson</a>, <a href="https://theconversation.com/institutions/rmit-university-1063">RMIT University</a></em></p> <p>Influenza, or the flu, is a virus transmitted by respiratory droplets from coughing and sneezing. It can cause the sudden onset of a fever, cough, runny nose, sore throat, headache, muscle and joint pain.</p> <p>In Australia, the flu is responsible for <a href="https://www1.health.gov.au/internet/main/publishing.nsf/Content/cda-cdi4004f.htm">more than 5,000 hospitalisation and 100 deaths</a> a year. The highest rates are among those over 65, whose immune systems aren’t as effective as they used to be, and children under five, whose immune systems are yet to mature.</p> <p>To combat the decline in immunity as we age, specific vaccines are available for people aged 65 and over. So how do they work, and why exactly are they needed?</p> <h2>Remind me, how does the immune system work?</h2> <p>The immune system uses multiple mechanisms to fight viral infections, which can be divided into two major arms of the immune system, called innate and adaptive immunity.</p> <p>Innate immunity involves multiple inflammatory cells and chemicals that are triggered immediately, or within hours of encountering an infection. They activate the immune system to clear the infection.</p> <p>Adaptive immunity takes a little longer (weeks) to work and involves memory T cells and antibody-producing B cells, which can be reactivated when the body encounters a virus or other pathogen.</p> <p>The combined innate and adaptive immune response determines how well we respond to an invading virus like influenza.</p> <h2>Why are older people more at risk from the flu?</h2> <p>Generally, as we age past 65, the innate cells become less effective at their job of clearing infections. They also start <a href="https://www.annualreviews.org/doi/full/10.1146/annurev-cellbio-100616-060718">producing more inflammation</a>.</p> <p>New T and B cell numbers also decrease with increasing age and hence the adaptive immune response is also not as effective as when we are younger. This immune system decline is called immunosenescence, which leads to increased susceptibility, hospitalisation and death from influenza.Certain medical conditions, such as cancer and heart and lung conditions, increase susceptibility to severe influenza, with older people being more likely to have additional medical conditions than younger people.</p> <h2>What flu vaccines are available?</h2> <p><a href="https://www.health.gov.au/topics/immunisation/vaccines/influenza-flu-vaccine">Annual flu vaccines</a> are recommended to protect against the common circulating strains of influenza, which can differ from year to year.</p> <p>The standard flu vaccines offered to adults aged under 65 consist of surface proteins of the virus or inactivated (killed) virus from four influenza strains: two A strains (H1N1 and H3N2) and two B strains.</p> <p>When you’re vaccinated, your immune system makes antibodies from B cells which protect you if you become exposed to these strains of the virus.</p> <p>However, the standard influenza vaccine is less effective in older people. Two stronger or augmented vaccines have been made targeting this age group. They contain the same components as the standard vaccine, but one vaccine – called <a href="https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&amp;id=CP-2020-CMI-01074-1&amp;d=20230529172310101">Fluad</a> – uses a strong adjuvant (an agent used to increase the immune response to vaccination) called MF59 to stimulate better immunity.</p> <p>The other augmented vaccine, called <a href="https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&amp;id=CP-2020-CMI-02062-1">Fluzone</a>, uses a four-fold higher dose of each influenza strain to increase immunity.</p> <h2>How do they compare?</h2> <p><a href="https://academic.oup.com/cid/article/73/11/e4251/5992287?login=false">Studies comparing Fluad and Fluzone</a> show both vaccines stimulate stronger immunity against influenza than the standard flu vaccine and are therefore likely to provide better protection.</p> <p>Studies directly testing for improved clinical outcomes with vaccines for over-65s show a small benefit of receiving either of the vaccines over the standard vaccine, including a modest decrease in lab-confirmed influenza, <a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(17)30235-7/fulltext">hospitalisations</a> and <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563546/">emergency department visits</a> compared to the standard influenza vaccine.</p> <p>They are however yet to show and impact on flu-related deaths.</p> <figure class="align-right "> </figure> <p>In the few studies comparing <a href="https://academic.oup.com/cid/article/73/11/e4251/5992287?login=false">Fluad and Fluzone directly</a>, there is little evidence of a difference between them in reducing influenza and serious flu outcomes. <a href="https://www.health.gov.au/resources/publications/atagi-advice-on-seasonal-influenza-vaccines-in-2023">The Australian Technical Advisory Group on Immunisation therefore recommends</a> using either Fluad or Fluzone.</p> <p>While both have been Therapeutic Goods Administration (TGA) approved since 2020, only Fluad is available for free on the National Immunisation Program for people aged 65 and over.</p> <p>Fluzone is only available with a private prescription if you’re 60 years and over, at a cost of around A$65-70.</p> <p>If neither augmented vaccine is available, a standard influenza vaccine is also acceptable for older people, since any influenza vaccine is preferable to receiving none.</p> <p>Flu vaccines can also be given at the same time as COVID vaccines.</p> <h2>How else can we protect against the flu?</h2> <p>While influenza vaccination is the single most effective way of preventing influenza, other measures such as social distancing and wearing a mask or N95 respirator can also provide some <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779801/">community protection</a>.</p> <p>Wearing a mask or N95 respirator significantly <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779801/">reduces the risk</a> of infecting others when infected.</p> <p>The evidence for protecting oneself against infection is less conclusive, mainly because it’s linked to early, consistent and, importantly, the <a href="https://cdn.who.int/media/docs/default-source/influenza/advice-on-the-use-of-masks-in-the-community-setting-in-influenza-a-(h1n1)-outbreaks.pdf?sfvrsn=24a45a95_1&amp;download=true">correct use of masks</a>.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/204810/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/magdalena-plebanski-1063786">Magdalena Plebanski</a>, Professor of Immunology, <a href="https://theconversation.com/institutions/rmit-university-1063">RMIT University</a>; <a href="https://theconversation.com/profiles/jennifer-boer-1210047">Jennifer Boer</a>, Postdoctoral Research Fellow, <a href="https://theconversation.com/institutions/rmit-university-1063">RMIT University</a>; <a href="https://theconversation.com/profiles/katie-louise-flanagan-1066858">Katie Louise Flanagan</a>, Infectious Diseases Specialist and Clinical Professor, <a href="https://theconversation.com/institutions/university-of-tasmania-888">University of Tasmania</a>, and <a href="https://theconversation.com/profiles/kirsty-wilson-1103649">Kirsty Wilson</a>, Postdoctoral Research Fellow, <a href="https://theconversation.com/institutions/rmit-university-1063">RMIT University</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/im-over-65-and-worried-about-the-flu-which-vaccine-should-i-have-204810">original article</a>.</em></p>

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"I'm glad you're resigning": Kochie's run-in with a heckler

<p>David Koch has shared the details of a nasty altercation he had with a stranger after announcing his departure from <em>Sunrise</em>. </p> <p>Kochie <a href="https://oversixty.com.au/news/news/the-world-s-best-job-kochie-quits-sunrise" target="_blank" rel="noopener">announced</a> on Monday that he would be leaving the Channel Seven breakfast show after 20 years in the hosting chair. </p> <p>The response to his shock resignation has been mostly positive and supportive, as famous friends and loyal viewers have flooded online spaces with well wishes for the veteran TV presenter. </p> <p>However, Kochie shared that after taping had finished for Monday morning's show, he was approached by a heckler on the street while walking with his wife, Libby.</p> <p>“In all of that lovely euphoria, this is just life, I’m walking to lunch with Lib and walked by a bloke and he goes, ‘I’m glad you’re resigning, you are just a paid mouthpiece for Big Pharma’,” Koch said.</p> <p>“An anti-vaxxer. He started yelling at me across the road. Lib’s going ‘What the hell?’.”</p> <p>Koch’s co-host Natalie Barr said, “We take the good with the bad, and we know that.”</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Kochie has thanked all the well-wishers who responded to the news he is leaving Sunrise, before revealing one random heckler gave him a send-off to forget! <a href="https://twitter.com/kochie_online?ref_src=twsrc%5Etfw">@kochie_online</a> <a href="https://twitter.com/hashtag/kochie?src=hash&amp;ref_src=twsrc%5Etfw">#kochie</a> <a href="https://twitter.com/hashtag/sunriseon7?src=hash&amp;ref_src=twsrc%5Etfw">#sunriseon7</a> <a href="https://t.co/uhUhxONeNN">pic.twitter.com/uhUhxONeNN</a></p> <p>— Sunrise (@sunriseon7) <a href="https://twitter.com/sunriseon7/status/1663321697208918018?ref_src=twsrc%5Etfw">May 29, 2023</a></p></blockquote> <p>Speaking to <a href="https://www.news.com.au/entertainment/tv/morning-shows/david-koch-reveals-he-was-brutally-sledged-in-street-after-quitting-sunrise/news-story/551069985f00f3a4909a32502b4aae91" target="_blank" rel="noopener"><em>news.com.au</em></a>, Koch said that after decades in the game, he was okay with not pleasing everybody.</p> <p>“Yes, we all have faults. I’ve stuffed up and people love me or hate me, but what they see is what they get, and I think they respect that even if they disagree with your views,” he said.</p> <p>“It’s a really intimate relationship with the viewers.”</p> <p>Despite the heckler, Kochie went on to say he had received a lot of kind messages, with one of the nicest tributes coming form his breakfast TV show rival Karl Stefanovic. </p> <p>“A wonderful, classy, respectful [message] from Karl Stefanovic was so nice, really adored that one,” he said on-air.</p> <p>“But so many great messages.”</p> <p><em>Image credits: Sunrise</em></p> <div class="media image" style="caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; box-sizing: inherit; display: flex; flex-direction: column; align-items: center; width: 705.202209px; margin-bottom: 24px; max-width: 100%;"> </div>

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Should I get a flu vaccine this year? Here’s what you need to know

<p><em><a href="https://theconversation.com/profiles/paul-griffin-1129798">Paul Griffin</a>, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a></em></p> <p>After having low rates of influenza (flu) transmission in recent years thanks to our COVID control strategies, case numbers are now rising.</p> <p>So far this year, Australia has had <a href="https://www.immunisationcoalition.org.au/news-data/influenza-statistics/">more than 32,000</a> lab-confirmed cases of the flu and 32 deaths.</p> <p>Getting a flu vaccine is the best way to protect against getting the flu. These are reformulated each year to protect against the most widely circulating strains – if our predictions are right.</p> <p>Below you’ll find everything you need to know about the 2023 flu vaccine. But first, some flu basics.</p> <h2>What are the different types of flu?</h2> <p>There are two main types of influenza: influenza A and influenza B. On the surface of the influenza virus there are two main proteins, the hemagglutinin (HA or H) and neuraminidase (NA or N).</p> <p>Different strains are named after their versions of the H and N proteins, as in H1N1 or “swine flu”.</p> <figure class="align-center "><img src="https://images.theconversation.com/files/525044/original/file-20230509-15-c78c12.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/525044/original/file-20230509-15-c78c12.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=396&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/525044/original/file-20230509-15-c78c12.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=396&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/525044/original/file-20230509-15-c78c12.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=396&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/525044/original/file-20230509-15-c78c12.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=498&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/525044/original/file-20230509-15-c78c12.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=498&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/525044/original/file-20230509-15-c78c12.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=498&amp;fit=crop&amp;dpr=3 2262w" alt="" /><figcaption><span class="caption">HA is the yellow spike, while the NA is the green oval.</span> <span class="attribution"><a class="source" href="https://www.shutterstock.com/image-vector/structure-influenza-virus-infographics-vector-illustration-542924464?src=ixiW0w-59I3I17RpN4L3wQ-1-12">Shutterstock</a></span></figcaption></figure> <p>Minor changes in the proteins (HA and NA) on the surface are common because the enzyme the virus uses to make copies of itself is prone to errors.</p> <p>Sometimes the influenza virus can change more abruptly when it mixes up components from different influenza viruses – including influenza viruses that typically infect birds, pigs or bats – to create a virus that’s basically new.</p> <p>The regular change in the virus is the reason the vaccine is updated every year. The <a href="https://www.tga.gov.au/about-tga/advisory-bodies-and-committees/australian-influenza-vaccine-committee-aivc">Australian Influenza Vaccine Committee</a> meets late in the year to plan what should be included in the vaccine for the following season, after considering what happened in our last flu season and in the Northern hemisphere winter.</p> <h2>What strains does this year’s flu shot protect against?</h2> <p>Modern flu vaccines typically protect against four strains. For this year’s vaccine, the committee <a href="https://www.tga.gov.au/resources/publication/meeting-statements/aivc-recommendations-composition-influenza-vaccines-australia-2023">has recommended</a> it includes:</p> <ul> <li> <p>an A/Sydney/5/2021 (H1N1)pdm09-like virus</p> </li> <li> <p>an A/Darwin/9/2021 (H3N2)-like virus</p> </li> <li> <p>a B/Austria/1359417/2021 (B/Victoria lineage)-like virus</p> </li> <li> <p>a B/Phuket/3073/2013 (B/Yamagata lineage)-like virus.</p> </li> </ul> <p>The naming of the viral components can sometimes be confusing. The name is <a href="https://www.cdc.gov/flu/about/viruses/types.htm">derived from</a> the virus type (A or B)/the place it was first isolated/strain number/year isolated (virus subtype).</p> <p>This year’s vaccine therefore includes an influenza A virus similar to the 2009 pandemic-causing H1N1 isolated from Sydney in 2021 and a second influenza A virus (H3N2) isolated in Darwin in 2021.</p> <p>Influenza B viruses are classified into 2 lineages: Victoria and Yamagata. This year’s vaccine includes an influenza B isolated from Austria in 2021 (Victoria lineage) and an influenza B isolated in Phuket in 2013 (Yamagata lineage).</p> <h2>Who should get a flu shot?</h2> <p>Health authorities <a href="https://www.health.gov.au/topics/immunisation/vaccines/influenza-flu-vaccine">recommend</a> everyone aged six months of age or over should get the flu vaccine every year.</p> <p><a href="https://www.health.gov.au/news/2023-national-immunisation-program-influenza-vaccination-early-advice-for-vaccination-providers">Some groups</a> are at greater risk of significant disease from the flu and can access the flu vaccine for free. This includes:</p> <ul> <li> <p>Aboriginal and Torres Strait Islander people aged six months and over</p> </li> <li> <p>children aged six months to five years</p> </li> <li> <p>pregnant women at any stage of pregnancy</p> </li> <li> <p>people aged 65 years or over</p> </li> <li> <p>people aged five years to 65 years who have certain underlying health conditions affecting the heart, lungs, kidneys or immune system, and those with diabetes.</p> </li> </ul> <h2>How can I get it?</h2> <p>You can get a flu shot from your local general practice or pharmacy. Or you may have an opportunity to get vaccinated at your workplace if your employer supplies it.</p> <p>While the vaccine is free for those in the <a href="https://www.health.gov.au/sites/default/files/2023-02/fighting-flu-starts-with-you-consumer-fact-sheet.pdf">above groups</a>, there can be a consultation or administration fee, depending on where you get your vaccine.</p> <p>If you aren’t eligible for a free vaccine, it usually costs around A$20-$30.</p> <h2>Are there different options?</h2> <p>For over 65s, whose immune systems may not work as well as when they were younger, a <a href="https://www.health.gov.au/sites/default/files/2023-03/atagi-advice-on-seasonal-influenza-vaccines-in-2023.pdf">specific vaccine</a> is available that includes an adjuvant which boosts the immune response. This is free for over-65s under the national immunisation program.</p> <p>A high-dose vaccine is also available for people aged 60 and over. However this isn’t currently funded and costs around $70 on a private prescription.</p> <p>People with egg allergies can safely get the egg-based flu vaccine. However there is also a cell-based immunisation for people who don’t want a vaccine made in eggs. When vaccines are grown in eggs, sometimes the virus can change and this might affect the level of protection. Cell-based vaccines aim to address this issue.</p> <p>The cell-based vaccine isn’t funded so patients will pay around $40 for a private prescription.</p> <h2>How well do they work?</h2> <p>The vaccine’s effectiveness depends on how well the strains in the vaccine match those circulating. It generally <a href="https://www.health.gov.au/resources/publications/aisr-2022-national-influenza-season-summary">reduces</a> the chance of being admitted to hospital with influenza by <a href="https://www.health.gov.au/sites/default/files/documents/2022/08/influenza-vaccine-efficacy-effectiveness-and-impact-explained.docx">30-60%</a>.</p> <h2>What are the side effects?</h2> <p>You can’t get the flu from the vaccine as there’s no live virus in it.</p> <p>When people get a flu-like illness after the vaccine, it can be due to mild effects we sometimes see after vaccination, such as headaches, tiredness or some aches and pains. These usually go away <a href="https://www.health.gov.au/topics/immunisation/vaccines/influenza-flu-vaccine#possible-side-effects-of-influenza-vaccination">within a day or two</a>.</p> <p>Alternatively, symptoms after getting a flu shot may be due to another respiratory virus such as respiratory syncytial virus (RSV) that circulates in winter.</p> <h2>When’s the best time to get your flu shot?</h2> <p>The vaccine provides <a href="https://immunisationhandbook.health.gov.au/contents/vaccine-preventable-diseases/influenza-flu#vaccine-information">peak protection</a> around three to four months <a href="https://www.health.gov.au/topics/immunisation/vaccines/influenza-flu-vaccine#when-to-get-the-influenza-vaccine">after</a> you get it.</p> <p>The <a href="https://www.immunisationcoalition.org.au/news-data/influenza-statistics/">peak of the flu season</a> is usually between June and September, however this changes every year and can vary in different parts of the country.</p> <p>Given this, the best time to get the vaccine is usually around late April or early May. So if you haven’t already, now would be a good time to get it.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/203406/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/paul-griffin-1129798">Paul Griffin</a>, Associate Professor, Infectious Diseases and Microbiology, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/should-i-get-a-flu-vaccine-this-year-heres-what-you-need-to-know-203406">original article</a>.</em></p>

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The best anti-ageing secrets dermatologists won’t tell you for free

<p><strong>The best tips from top dermatologists </strong></p> <p>A wide array of over-the-counter anti-ageing skincare products aim to improve the signs of ageing, such as skin spots, fine lines, wrinkles, and boost collagen. Yet, most of these products are more hype – it’s important for consumers to understand when a product is a cosmetic, drug, or both to evaluate the validity of these claims. So, which products can actually deliver results that improve the signs of ageing?</p> <p>We spoke with medical experts who told us the best anti-ageing secrets for better skin health.</p> <p><strong>Opt for sunscreen to fight ageing skin</strong></p> <p>Sunscreen is one of the best weapons when it comes to protecting your skin against skin cancer, and it’s also one of the best ways to keep your skin looking younger and healthier. “The sun emits ultraviolet radiation that damages skin, both the overlying epidermis and the underlying dermis,” explains dermatologist, Dr Jerome Garden. “In addition to increasing your risk of skin cancer, the sun causes brown spots, red spots, and wrinkles.”</p> <p><strong>Expensive products are not always more effective</strong></p> <p>It may be tempting to splurge on a skin-care item that promises to yield worthy results, but pricey doesn’t always equal quality. There are some great inexpensive products that can produce great results, according to dermatologist, Dr Dendy Engelman. “A higher price tag can mean better quality ingredients or a higher concentration of an ingredient, but the ingredients list is always more important than the brand selling the product,” she says.</p> <p><strong>Don't buy generic skincare</strong></p> <p>You don’t need to spend a fortune to get a high-quality skincare product, but there is a difference between a brand name product and a generic one, according to dermatologist, Dr Joshua Zeichner.</p> <p>“Many generic products are packaged to look similar to the original, and may even have the same ingredients list, however, the difference is the quality of the ingredients and how they are actually formulated,” he says.</p> <p><strong>Skimp on a fancy cleanser</strong></p> <p>No matter what an expensive cleanser may cost, it’s not going to work any more magic than most lower-cost competitors, according to dermatologists. “The goal of a cleanser is to remove dirt, oil, makeup and pollution from the skin without disrupting the outer skin layer – and the ingredients used to create a product that can do this are not expensive,” says Dr Zeichner. “In fact, some of the best quality cleansers are actually among the least expensive products on the market.”</p> <p><strong>Opt for a serum</strong></p> <p>Serums, which are meant to be layered underneath your daily and nightly moisturiser, often are the first skincare products to be skipped. But, they actually play an important role in your daily routine. “Serums contain a high concentration of active ingredients and are lightweight, so they penetrate deeper into your skin to provide maximum benefits,” says dermatologist, Dr Whitney Bowe.</p> <p>She recommends looking for serums that contain ceramides and amino acids, which help to bolster the skin’s natural barrier, and antioxidants, which protect skin from sun damage and free radicals.</p> <p><strong>Don't trust anti-wrinkle face cream claims </strong></p> <p>“We develop fine lines because of repeated folding of the skin from underlying muscles,” explains Dr Zeichner. “Young, healthy skin has a strong foundation that resists folding and bounces back to its original shape, but, with age, that skin foundation gets weaker.”</p> <p>While topical creams will certainly help keep the skin barrier strong, the only way to truly reduce wrinkles is to relax the muscles underneath the skin, according to Dr Zeichner.</p> <p><strong>Wear sunscreen year-round</strong></p> <p>It’s true that even on the cloudiest or snowiest of days, sunscreen should be a part of your daily skincare routine. “Incidental sun exposure for only 10 to 15 minutes a day adds up over time and can cause significant sun damage and accelerated photoaging,” says Dr Engelman.</p> <p>In order to keep skin looking its youngest and healthiest, she recommends applying sunscreen every single day of the year, as brief sun exposures throughout the year can add up to significant damage (think driving with the sunroof open or walking around outdoor shopping centres during peak sun hours).</p> <p><strong>Use retinol - it really works</strong></p> <p>According to dermatologist, Dr Hadley King, topical retinoids are the most effective topical anti-ageing products (after sun protection). “There is great data that supports their effectiveness and safety,” she says. “While prescription retinoids are the most effective, there are now plenty of over-the-counter products that contain retinol and work well, especially on those with sensitive skin.”</p> <p><strong>Invest in laser treatments</strong></p> <p>If you’re looking for fast results without the use of creams, Dr Garden recommends laser treatments, which he specialises in. “We have lasers for brown spots, red spots, blood vessels and wrinkles,” he says. “Newer devices called fractionated lasers can produce impressive results with less downtime than before.” Although they’re on the pricier side, he says that these treatments can offer results far superior to creams.</p> <p>But the only caveat is that these machines are powerful and, in many states, can be operated by unqualified individuals who are not even physicians. He recommends making sure that your laser treatments are being performed by a board-certified dermatologist to avoid complications.</p> <p><strong>Try collagen supplements </strong></p> <p>Collagen is a protein that’s a building block for our hair, skin and nails. “Supplemental collagen is fragmented pieces of amino acids and peptides that connect in the bloodstream with enzymes that trigger the production of collagen,” explains Dr Engelman. “In a collagen-deficient system, this will support and increase collagen production.” It’s important, however, that you choose the right type of collagen, since 16 different strains exist.</p> <p>“For oral supplements, hydrolysed collagen is easiest to digest, as it is broken down into the smallest forms of peptides and amino acids,” she says. “I like pills and powders because they are easy to incorporate no matter what your lifestyle.”</p> <p><strong>Don't fall for 'trendy' products</strong></p> <p>The latest and greatest products on the market might be eye-catching, but their popularity doesn’t mean that they’re effective. “Just because something is ‘hot’ right now in the beauty industry, does not mean that you should run out to purchase it,” says Dr Bowe. “I always encourage my patients to look for scientific studies and statistics which prove that products deliver the results they promise.”</p> <p><strong>Follow a healthy diet</strong></p> <p>No matter how much time, energy and money you spend on your skincare regimen, if you’re not supplementing it with a healthy diet, you’re wasting your efforts, according to experts. “Your skin is a reflection of your overall health and wellness and your diet absolutely impacts the appearance and health of your skin,” says Dr Bowe.</p> <p>“For example, sugar in any form causes multiple changes in our body, from our cellular membranes and our arteries to our hormones, immune systems, gut, and even microbiome – the microbes in our intestines that affect our biology all the way out to our skin.”</p> <p><strong>Allergy pill and a nap may reduce dark circles and puffy eyes</strong></p> <p>There are other causes of dark circles that are unrelated to your skin, such as seasonal allergies or lack of sleep. Dermatologist, Dr Joel Schlessinger recommends trying Clarityne or Zyrtec, drinking more water, or heading to bed an hour earlier to clock in more sleep. If your dark circles and puffiness aren’t improved by any of those suggestions, then he says a well-formulated and hydrating eye cream could help.</p> <p><strong>Avoid sleeping on your side</strong></p> <p>Believe it or not, the way you sleep does have an effect on the smoothness of your skin. “Sleeping on your side presses your cheek into the pillow and causes the skin on your chest to be scrunched, creating new or reinforcing existing wrinkles,” warns Dr Schlessinger. “Train yourself to sleep on your back as much as you can – it will keep skin as flat and smooth as possible.”</p> <p><strong>Don't wait until it's too late too start Botox</strong></p> <p>Some fine lines and wrinkles are caused by repetitive movements, so starting these treatments early, even in your late 20s and early 30s, may potentially help prevent them or slow their progression, according to cosmetic dermatologist, Dr Sejal Shah.</p> <p>“People are often afraid of injectables because they don’t want to look ‘frozen’ or overdone, but many neurotoxins (Botox, Dysport, Xeomin, and Jeuveau) can look very natural when appropriately placed.” Just be sure to seek treatment from trained individuals, such as a board-certified dermatologist.</p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://www.readersdigest.com.au/healthsmart/beauty/the-best-anti-ageing-secrets-dermatologists-wont-tell-you-for-free?pages=1" target="_blank" rel="noopener">Reader's Digest</a>. </em></p>

Beauty & Style

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“Putrid cookers”: Anti-vaxxers slammed for spreading lies about Jock Zonfrillo’s death

<p dir="ltr">Just hours after MasterChef judge Jock Zonfrillo’s sudden death, heartless anti-vaxxers took to social media to spread disinformation.</p> <p dir="ltr">Zonfrillo died in Melbourne on May 1. While the cause of death has not been publicly announced, police said that his death was not being treated as suspicious, and a report was made for the coroner.</p> <p dir="ltr">The anti-vaxxers took this as a chance to spread disinformation online, implying that his death was linked to the Covid vaccine.</p> <p dir="ltr">“Did Jock Zonfrillo get the Pfizer or Moderna RNA vaccine?” one person tweeted the day after his death.</p> <p dir="ltr">Another commented on the way that his death was described as “sudden” with no confirmed cause- completely ignoring the fact that Zonfrillo’s family have not released that information.</p> <p dir="ltr">“The mainstream media has been reporting countless such ‘sudden deaths’ with ‘no cause of death given’,” wrote the anti-vaxxer on Facebook on May 2.</p> <p dir="ltr">“Since when are death reports being provided with no cause given?</p> <p dir="ltr">“I know since when: since they rolled out those experimental Covid vaccines, which are dropping people faster than they can clue in that it is murdering them. The mainstream media and medical establishment will never admit it – they omit the REAL reason someone died by saying ‘no immediate cause of death was given’,” wrote another.</p> <p dir="ltr">The ill-informed comments have attracted significant backlash from Aussies who slammed the “cookers” for taking advantage of the tragedy to spread disinformation.</p> <p dir="ltr">“Of course the putrid cookers have already come out, saying it was the Covid vaccine that killed Jock Zonfrillo. They really are opportunistic scum. RIP Jock,” one person tweeted in response to the lies.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Of course the putrid cookers have already come out, saying it was the covid vaccine that killed Jock Zonfrillo. <br />They really are opportunistic scum.<br />RIP Jock. <a href="https://t.co/t7jxe9QX1P">pic.twitter.com/t7jxe9QX1P</a></p> <p>— JayJay (@JayJay91341991) <a href="https://twitter.com/JayJay91341991/status/1653215630768865281?ref_src=twsrc%5Etfw">May 2, 2023</a></p></blockquote> <p dir="ltr">“I’m always unsurprised at the amount of cookers that come out of the woodwork when a celebrity dies. Shame on anyone who is using Jock Zonfrillo’s death to push their anti-vax vile rhetoric,” tweeted another.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">I’m always unsurprised at the amount of cookers that come out of the woodwork when a celebrity dies. Shame on anyone who is using Jock Zonfrillo’s death to push their anti-vax vile rhetoric.</p> <p>— MrDreeps (@MrDreepy) <a href="https://twitter.com/MrDreepy/status/1652947746419281921?ref_src=twsrc%5Etfw">May 1, 2023</a></p></blockquote> <p dir="ltr">“Distance yourself from people who impulsively attribute the death of a celebrity to the Covid-19 Vaccine.</p> <p dir="ltr">“It demonstrates extreme congruence bias, and a profound lack of empathy. #jockzonfrillo,” wrote a third.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Distance yourself from people who impulsively attribute the death of a celebrity to the Covid-19 Vaccine. </p> <p>It demonstrates extreme congruence bias, and a profound lack of empathy. <a href="https://twitter.com/hashtag/jockzonfrillo?src=hash&ref_src=twsrc%5Etfw">#jockzonfrillo</a></p> <p>— Nick Holt (@realnickholt) <a href="https://twitter.com/realnickholt/status/1652919969926254592?ref_src=twsrc%5Etfw">May 1, 2023</a></p></blockquote> <p dir="ltr"><em>Images: Instagram</em></p> <p dir="ltr"> </p>

News

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"Stay away!": City forced into bizarre anti-travel campaign

<p>Amsterdam has taken desperate measures in the fight to keep the city safe from “messy” tourists determined to cause chaos and call it a night out. </p> <p>The Dutch capital’s new online campaign sets out to primarily tackle the problem of young British men, warning them against their plans to “let loose” while they’re visiting. </p> <p>Hopeful British tourists - between the ages of 18 and 35 - who google things like “stag party Amsterdam”, “pub crawl Amsterdam”, and “cheap hotel Amsterdam” will be made to view short videos that stress the consequences that come with “[causing] nuisance and excessive alcohol and drug use”, according to a statement from the city’s local authorities. </p> <p>One of said videos shows an intoxicated young man being arrested after insulting police officers, with text reading: “Coming to Amsterdam for a messy night + getting trashed = €140 fine + criminal record = fewer prospects.” </p> <p>From there comes the firm and to-the-point statement: “So coming to Amsterdam for a messy night? Stay away.”</p> <p>In another of the campaign’s videos, an unconscious individual can be seen in an ambulance as it rushes to hospital, this time with text that reads: “Coming to Amsterdam to take drugs + lose control = hospital trip + permanent health damage = worried family.” </p> <p>It concludes with the same message as the other. </p> <p>Amsterdam welcomes approximately 20 million tourists each year, and is well known for its red light district. It’s this same hotspot that has played a major role in establishing the city as the place to party in Europe. </p> <p>However, local residents have voiced their displeasure for years, fed up with the chaos that drunken tourists bring their way, and prevent them from enjoying their own city as they want to. </p> <p>“Visitors will remain welcome, but not if they misbehave and cause nuisance. In that case we as a city will say: rather not, stay away,” Amsterdam’s deputy mayor Sofyan Mbarki said.</p> <p>“Amsterdam is already taking lots of measures against excessive tourism and nuisance, and we are taking more measures than other large cities in Europe. But we have to do even more [in] the coming years if we want to give tourism a sustainable place in our city.”</p> <p>From there, he went on to note that in order to keep their city a liveable place, they had to turn their attention to “restriction instead of irresponsible growth.” </p> <p>This isn’t the only - or even first - step city officials have taken towards achieving their goal, having just passed new regulations that make it illegal for anyone to smoke cannabis while in the red light district. </p> <p>The video campaign may yet expand to include visitors from beyond the UK, authorities have suggested. They also plan to launch another campaign called “How to Amsterdam”, which aims to reign in tourists already visiting. This campaign will utilise social media and street signs, with warnings about everything from drunkenness to noise, drugs, and urinating in public. </p> <p>Providers who offer bachelor party experiences have reportedly been contacted by the council as well, in the hope that they can reduce - and prevent - trouble in the city’s centre, while they also await the results of research into a potential tourist tax. </p> <p><em>Images: YouTube</em></p>

Travel Trouble

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Tech millionaire’s “creepy” $100k offer sparks wave of backlash

<p>US tech millionaire and Silicon Valley entrepreneur Steve Kirsch has been slammed for making a “creepy” offer towards a female passenger who was travelling on the same plane.</p> <p>In a tweet, Kirsch claimed that he offered the stranger $US100,000 to remove her face mask for the flight.</p> <p>"I am on board a Delta flight right now. The person sitting next to me in first-class refused $100,000 to remove her mask for the entire flight. No joke," he tweeted.</p> <p>Kirsch, who became infamous for spreading misinformation about the COVID-19 vaccines throughout the pandemic, said that he "explained" to his seatmate that masks "don’t work".</p> <p>He also claims that the woman worked for a pharmaceutical company, and he started by offering her $US100 but worked his way up.</p> <p>She rejected his offer, but Kirsch persisted and said that if she removed the mask to eat and drink she "she could be infected with one breath".</p> <p>Many have slammed the entrepreneur for his actions.</p> <p>“Ew. Do you make a habit of offering money to random women to remove coverings from their bodies mid-air?" posted Jess Piper, a former Democrat state representative nominee, in her response to Kirsch's post.</p> <p>“Stop bugging people who are minding their own business with your creepy nonsense,” commented Alastair McAlpine, an infectious disease expert.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">I am on board a Delta flight right now. The person sitting next to me in first class refused $100,000 to remove her mask for the entire flight. No joke. This was after I explained they don’t work. She works for a pharma company. <a href="https://t.co/Q8Hwzhkmxf">pic.twitter.com/Q8Hwzhkmxf</a></p> <p>— Steve Kirsch (@stkirsch) <a href="https://twitter.com/stkirsch/status/1634189428150390785?ref_src=twsrc%5Etfw">March 10, 2023</a></p></blockquote> <p>"This is wildly creepy, you get that, right? Every part of this. From the request, to the expression, to the fact you decided to tweet this!" commented one user.</p> <p>“All you’re doing here is admitting you patronised and harassed a woman who made a decision she thought was best for her,” wrote another.</p> <p>Last week, Kirsch tried to pull the same stunt on a different flight.</p> <p>He tweeted that he offered his seatmates $US10,000 to remove their masks for the flight, but they also declined his offer.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">I asked the people sitting next to me on the plane if I paid them $10,000 would they remove their mask for the duration of the flight? Both declined the offer. </p> <p>Maybe I should offer $100,000 next time? This can quantify the amount of brainwashing. <a href="https://t.co/VLlymusmcq">pic.twitter.com/VLlymusmcq</a></p> <p>— Steve Kirsch (@stkirsch) <a href="https://twitter.com/stkirsch/status/1633166204054675456?ref_src=twsrc%5Etfw">March 7, 2023</a></p></blockquote> <p>"Maybe I should offer $100,000 next time? This can quantify the amount of brainwashing," he added.</p> <p>Delta airlines have said that masks are optional for both domestic and international travel unless required by “applicable governments”.</p> <p>American federal law no longer requires masks be worn in airports or on planes, but certain cities and states may still make it a requirement at their airports.</p> <p><em>Image: Twitter</em></p>

Travel Trouble

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Fran Drescher calls for an end to “bull***t” vaccine mandates

<p dir="ltr">Fran Drescher has divided audiences after using her platform to go on a tirade about bringing an end to “bull***t” vaccine mandates. </p> <p dir="ltr">The former star of <em>The Nanny</em> took to the stage at the 2023 Screen Actors Guild (SAG) Awards on Sunday, and used the opportunity to voice her controversial opinions about Covid-19 restrictions. </p> <p dir="ltr">“As the nation declares an end to the Covid emergency this May, I hope we will see everyone return to work in equal opportunity,” Drescher, 65, said in her speech during the telecast,<em> <a href="https://nypost.com/2023/02/27/fran-drescher-calls-for-end-to-vaccine-mandate-in-sag-speech/?utm_campaign=SocialFlow&amp;utm_medium=SocialFlow&amp;utm_source=NYPTwitter">Page Six</a></em> reports. </p> <p dir="ltr">The entertainment industry’s pandemic protocols were originally set to end on January 31st, but have been extended until April 1st. </p> <p dir="ltr">Meanwhile, more than 20 US states still enforce vaccine mandates to varying degrees.</p> <p dir="ltr">“Our industry brings billions of production dollars to states across the nation, but if they want our business, let’s wield our financial influence to make governors act in the best interest of freedom, diversity, inclusion and democracy,” Drescher said.</p> <p dir="ltr">“As my character Bobbi Flekman said in <em>This Is Spinal Tap</em> – money talks and bulls**t walks!”</p> <p dir="ltr">Her divisive comments were met with a mixed reaction online, with many viewers claiming it was “irresponsible” for Drescher to use her platform in such a way.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Fran Drescher’s comments on the <a href="https://twitter.com/hashtag/CovidVaccine?src=hash&amp;ref_src=twsrc%5Etfw">#CovidVaccine</a> were irresponsible. Using her logic, people wouldn’t be universally vaccinated against diseases like measles and tetanus. Public health is PUBLIC because it takes collective work.</p> <p>— 🇺🇦мег 🇺🇦 (@sassybibrarian) <a href="https://twitter.com/sassybibrarian/status/1630038810095648768?ref_src=twsrc%5Etfw">February 27, 2023</a></p></blockquote> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">God I love Fran Drescher, but her speech at the SAG awards could have been an email.</p> <p>— Francis (@Fusterduster) <a href="https://twitter.com/Fusterduster/status/1630022506668249088?ref_src=twsrc%5Etfw">February 27, 2023</a></p></blockquote> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Woody Harrelson and now Fran Drescher. Big weekend for anti-vaxxers.</p> <p>— 𝐓𝐨𝐦𝐚𝐬 ⁽ʷʰᵒ ⁱˢ ᵍᵃʸ⁾ (@cinema_gay) <a href="https://twitter.com/cinema_gay/status/1630021950293655554?ref_src=twsrc%5Etfw">February 27, 2023</a></p></blockquote> <p dir="ltr">Elsewhere in her speech, Drescher also discussed her efforts to help make Hollywood more environmentally friendly by joining with Green Council with a goal to eliminate single-use plastic both on camera and behind the scenes.</p> <p dir="ltr">She also applauded IMDb for “taking a stand against ageism, stereotyping and gender rigidity by allowing our members to define themselves their way on their profile page – for free.”</p> <p dir="ltr"><em>Image credits: Getty Images</em><span id="docs-internal-guid-1cf5b55a-7fff-4610-144c-c7e3ae12e9d4"></span></p>

Body

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Six-month-old children to receive COVID-19 vaccine in new recommendations

<p>The US Centers for Disease Control and Prevention (CDC)’s Advisory Committee on Immunization Practices (ACIP) has updated its 2023 immunisation schedule for children and individuals under the age of 18.</p> <p>COVID-19 vaccinations were included in the new recommendations for routine children inoculations in the United States, but it remains to be seen whether or not Australia will take the same measure into consideration - one leading infectious diseases physician is doubtful. </p> <p>For children in the United States, the schedule comes only as a recommendation and not as a mandate. The COVID-19 vaccinations will now feature alongside the likes of other common vaccinations for the measles, MMR, mumps, polio, chickenpox, and the flu. </p> <p>It was last year in 2022 that the CDC first recommended COVID-19 vaccination for children of six months and up, but it has only now been formalised. </p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">US vaccine schedule kids 0-6 years <a href="https://t.co/n3X0vQEGUm">pic.twitter.com/n3X0vQEGUm</a></p> <p>— Irene Tosetti, MD MBA MPH (@itosettiMD_MBA) <a href="https://twitter.com/itosettiMD_MBA/status/1624741715134357506?ref_src=twsrc%5Etfw">February 12, 2023</a></p></blockquote> <p>Professor Robert Booy from the University of Sydney’s Infectious Diseases Institute spoke to <em>SBS News</em> about the United State’s approach to their vaccination recommendations, suggesting they may be “a bit gung-ho”. </p> <p>“They're recommending vaccinations even for children who are at mild risk," he said, “they're recommending vaccinations to all children."</p> <p>Professor Booy went on to add that he does not believe Australia will follow in the US’ footsteps, and that the vaccination is unlikely to be recommended for babies here. </p> <p>"We're taking the approach that vaccination is for children who are vulnerable - children who are at high risk and who have multiple medical problems or disability,” he explained. </p> <p>On the subject of Australia’s childhood vaccinations, he stated that the country is “not standing out”, as the United Kingdom is “more conservative” and equally unlikely to adopt the new US recommendations. </p> <p>“We're just doing similar to other countries,” he said. “The US is standing out by being a bit 'gung-ho' in recommending vaccination to all children under five."</p> <p>Dr Deepti Gurdasani, a clinical epidemiologist and statistical geneticist from the United Kingdom, took to Twitter to share her belief that the UK and Australia were unlikely to follow. </p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">The US has added COVID vaccines to their routine childhood immunisation schedule from 6 months onwards. Will other countries follow? Feel little hope that this will happen in the UK or perhaps even Australia. <a href="https://t.co/NvFB8gK2I7">https://t.co/NvFB8gK2I7</a></p> <p>— Dr. Deepti Gurdasani (@dgurdasani1) <a href="https://twitter.com/dgurdasani1/status/1624758319188692993?ref_src=twsrc%5Etfw">February 12, 2023</a></p></blockquote> <p>At this stage, Australians aged five and up are recommended to receive a COVID-19 vaccination. However, the vaccinations are still recommended for children from six months to five years who are immunocompromised, have a disability, or have health conditions that increase their risk of severe COVID-19 symptoms.</p> <p><em>Images: Getty </em></p>

Caring

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Former MP reveals "devastating" Covid vaccine side effects

<p>Former federal MP Dr Kerryn Phelps has revealed both she and her wife have suffered continual health issues after receiving the Covid vaccine, while implying the true rate of adverse effects is higher than reported. </p> <p>In an explosive submission to Parliament’s Long Covid inquiry, the former Australian Medical Association (AMA) president has broken her silence about the "devastating" experience. </p> <p>“This is an issue that I have witnessed first-hand with my wife who suffered a severe neurological reaction to her first Pfizer vaccine within minutes, including burning face and gums, paraesethesiae, and numb hands and feet, while under observation by myself, another doctor and a registered nurse at the time of immunisation,” the 65-year-old said.</p> <p>“I continue to observe the devastating effects a year-and-a-half later with the addition of fatigue and additional neurological symptoms including nerve pains, altered sense of smell, visual disturbance and musculoskeletal inflammation. The diagnosis and causation has been confirmed by several specialists who have told me that they have seen ‘a lot’ of patients in a similar situation.”</p> <p>“Jackie [Kerryn's wife] asked me to include her story to raise awareness for others,” she said.</p> <p>“We did a lot of homework before having the vaccine, particularly about choice of vaccine at the time. In asking about adverse side effects, we were told that ‘the worst thing that could happen would be anaphylaxis’ and that severe reactions such as myocarditis and pericarditis were ‘rare’.”</p> <p>Dr Phelps revealed she was also diagnosed with a <a href="https://www.news.com.au/finance/economy/federal-budget/covid-vaccine-injury-payouts-explode-to-77-million-budget-reveals/news-story/df39fcf430c6cadb487a9914df7a3422" target="_self" data-tgev="event119" data-tgev-container="bodylink" data-tgev-order="df39fcf430c6cadb487a9914df7a3422" data-tgev-label="finance" data-tgev-metric="ev">vaccine injury</a> from her second dose of Pfizer in July 2021, “with the diagnosis and causation confirmed by specialist colleagues”.</p> <p>Dr Phelps said both reactions were reported to the Therapeutic Goods Administration (TGA) “but never followed up”.</p> <p>She revealed she had spoken with other doctors “who have themselves experienced a serious and persistent adverse event” but that “vaccine injury is a subject that few in the medical profession have wanted to talk about”.</p> <p>“Regulators of the medical profession have censored public discussion about adverse events following immunisation, with threats to doctors not to make any public statements about anything that ‘might undermine the government’s vaccine rollout’ or risk suspension or loss of their registration,” she said.</p> <p>“There has been a delay in recognition of vaccine injury, partly because of under-reporting, concerns about vaccine hesitancy in the context of managing a global pandemic, and needing to find the balance between risks and benefits on a population level.”</p> <p>According to the TGA’s most recent <a href="https://www.tga.gov.au/news/covid-19-vaccine-safety-reports/covid-19-vaccine-safety-report-15-12-2022" target="_self">safety update</a>, there have been a total of 137,141 adverse event reports from nearly 64.4 million doses — a rate of 0.2 per cent.</p> <p>There have been 819 reports “assessed as likely to be myocarditis” from 49.8 million doses of Pfizer and Moderna.</p> <p>Fourteen deaths have officially been linked to vaccination — 13 after AstraZeneca and one after Pfizer.</p> <p><em>Image credits: Getty Images </em></p>

News

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Thousands of Tasmanian devils are dying from cancer – but a new vaccine approach could help us save them

<p>Tasmanian devils are tough little creatures with a ferocious reputation. Tragically, each year thousands of Tasmanian devils suffer and die from contagious cancers – devil facial tumours.</p> <p>We have discovered that a modified virus, like the attenuated adenovirus used in the AstraZeneca COVID-19 vaccine, can make devil facial tumour cells more visible to the devil immune system.</p> <p>We have also found key immune targets on devil facial tumour cells. These combined advances allow us to move forward with a vaccine that helps the devil immune system find and fight the cancer.</p> <p>And we have a clever way to deliver this vaccine, too – with edible baits.</p> <p><strong>A puzzling cancer</strong></p> <p>Tasmanian devils mainly suffer from the original devil facial tumour, or DFT1. A second type of devil facial tumour (DFT2) has begun emerging in southern Tasmania that further threatens the already endangered devil population.</p> <p>DFT1 and DFT2 are <a href="https://www.tcg.vet.cam.ac.uk/about/DFTD">transmissible cancers</a> – they spread living cancer cells when the devils bite each other.</p> <p>This has presented a puzzle: a cancer cell that comes from another animal should be detected by the immune system as an invader, because it is “genetically mismatched”. For example, in human medicine, tissue transplants need to be genetically matched between the donor and recipient to avoid the immune system rejecting the transplant.</p> <p>Somehow, DFT1 and DFT2 seem to evade the immune system, and devils die from tumours spreading throughout their body or from malnutrition due to the facial tumours disrupting their ability to eat.</p> <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/495558/original/file-20221116-12-jv29a8.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/495558/original/file-20221116-12-jv29a8.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/495558/original/file-20221116-12-jv29a8.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=338&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/495558/original/file-20221116-12-jv29a8.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=338&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/495558/original/file-20221116-12-jv29a8.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=338&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/495558/original/file-20221116-12-jv29a8.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=424&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/495558/original/file-20221116-12-jv29a8.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=424&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/495558/original/file-20221116-12-jv29a8.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=424&amp;fit=crop&amp;dpr=3 2262w" alt="Close-up of a Tasmanian devil held by human hands, with a tumour on its lower jaw" /></a><figcaption><span class="caption">A Tasmanian devil with DFT1.</span> <span class="attribution"><span class="source">Andrew S. Flies @WildImmunity</span></span></figcaption></figure> <p>On the bright side, the immune systems of a few wild devils <em>have</em> been able to overcome DFT1. Furthermore, <a href="https://www.nature.com/articles/srep43827">previous vaccine and immunotherapy trials</a> showed the devil immune system can be activated to kill DFT1 cells and clear away sizeable tumours.</p> <p>This good news from both the field and the laboratory has allowed our team to zoom in on key DFT protein targets that the devil immune system can attack. This helps us in our quest to develop a more effective and scalable vaccine.</p> <p><strong>How can we vaccinate wild animals?</strong></p> <p>Even if we succeed in producing a <a href="https://doi.org/10.1080/14760584.2020.1711058">protective DFT vaccine</a>, we can’t trap and inject every devil.</p> <p>Luckily, clever researchers in Europe in the 1970s figured out that <a href="https://doi.org/10.1371/journal.pntd.0003953">vaccines can be incorporated into edible food baits</a> to vaccinate wildlife across diverse landscapes and ecosystems.</p> <p>In 2019, we hypothesised an oral bait vaccine could be made to protect devils from DFT1 and DFT2. Fast forward to November 2022 and the pieces of this ambitious project are falling into place.</p> <p>First, using samples from <a href="https://doi.org/10.1007/s00432-021-03601-x">devils with strong anti-tumour responses</a>, we have found that the main immune targets are <a href="https://doi.org/10.1098/rsob.220208">major histocompatibility proteins</a>. These are usually the main targets in transplant rejection. This tells us what to put into the vaccine.</p> <p>Second, we tested a virus-based delivery system for the vaccine. We used a weakened adenovirus most of the human population has already been exposed to, and found that in the lab this virus can enter devil facial tumour cells.</p> <p>Importantly, the weakened adenovirus can be modified to produce proteins that can <a href="https://doi.org/10.1099/jgv.0.001812">stimulate the devil immune system</a>. This means it forces the devil facial tumour cells to show the major histocompatibility proteins they normally hide, making the cells “visible” to cancer-killing immune cells.</p> <p>This vaccine approach is much like the AstraZeneca COVID-19 vaccine that uses a weakened chimpanzee adenovirus to deliver cargo to our immune system, getting it to recognise SARS-CoV-2. <a href="https://www.aphis.usda.gov/wildlife_damage/nepa/states/US/us-2019-onrab-ea.pdf">Adenoviral vaccines have also been widely used</a> in oral bait vaccines to protect raccoons from the rabies virus.</p> <p><strong>Edible protection</strong></p> <p>But there were additional challenges to overcome. Our collaborators in the USA who research and develop other wildlife vaccines suggested that developing an effective bait for devils might be as challenging as making the vaccine itself.</p> <p>Our first studies of placebo baits in the wild confirmed this. Contrary to previous studies which showed devils eating most of the baits, we found the baits were also readily consumed by other species, including eastern quolls, brushtail possums, and Tasmanian pademelons.</p> <p>This led us to test an automatic bait dispenser supplied by our collaborators at the US Department of Agriculture National Wildlife Research Center. The <a href="https://www.publish.csiro.au/WR/justaccepted/WR22070">dispensers proved quite effective</a> at reducing the amount of “off target” bait consumption and showed devils could successfully retrieve the baits with their dexterous paws.</p> <figure><iframe src="https://www.youtube.com/embed/5BEBfFqOY8k?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe><figcaption><span class="caption">Tasmanian devil retrieving a placebo bait from an automatic bait dispenser.</span></figcaption></figure> <p>Encouragingly, a recent mathematical modelling study suggests an <a href="https://lettersinbiomath.journals.publicknowledgeproject.org/index.php/lib/article/view/555">oral bait vaccine could eliminate DFT1</a> from Tasmania.</p> <p>Successful delivery of the vaccine would be a demanding and long-term commitment. But with it, we could prevent the suffering and deaths of thousands of individual devils, along with helping to reestablish a healthy wild devil population.</p> <p><strong>Can’t stop now</strong></p> <p>A bit of additional good news fell into place in late 2022 with the announcement that our international team was awarded an Australian Research Council Linkage Project grant to develop better baits and ways to monitor wildlife health in the field.</p> <p>These oral bait vaccine techniques that eliminate the need to catch and jab animals could be applied to future wildlife and livestock diseases, not just Tassie devils.</p> <p>Building on this momentum, we are planning to start new vaccine trials in 2023. We don’t know yet if this new experimental vaccine can prevent devils from getting devil facial tumours.</p> <p>However, the leap we have made in the past three years and new technology gives us momentum and hope that we might be able to stop DFT2 before it spreads across the state. Perhaps, we can even eliminate DFT1.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/194536/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em>Writen by Andrew S. Flies, </em><em>Chrissie Ong</em><em> and Ruth Pye. Republished with permission from <a href="https://theconversation.com/thousands-of-tasmanian-devils-are-dying-from-cancer-but-a-new-vaccine-approach-could-help-us-save-them-194536" target="_blank" rel="noopener">The Conversation</a>.</em></p> <p><em>Image: Getty Images</em></p>

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